Next Article in Journal
Acknowledgement to Reviewers of Antibiotics in 2014
Next Article in Special Issue
Augmentation of Cationic Antimicrobial Peptide Production with Histone Deacetylase Inhibitors as a Novel Epigenetic Therapy for Bacterial Infections
Previous Article in Journal
The Role of Antifungals against Candida Biofilm in Catheter-Related Candidemia
Previous Article in Special Issue
Structure-Dependent Immune Modulatory Activity of Protegrin-1 Analogs
Article Menu

Export Article

Open AccessReview
Antibiotics 2015, 4(1), 18-41; doi:10.3390/antibiotics4010018

Mechanisms of Antimicrobial Peptide Resistance in Gram-Negative Bacteria

Department of Microbiology and Immunology, Emory University, Atlanta, GA 30329, USA
Yerkes Primate Research Center, Emory University, Atlanta, GA 30329, USA
Emory Vaccine Center, Emory University, Atlanta, GA 30329, USA
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA
Author to whom correspondence should be addressed.
Academic Editor: William M. Shafer
Received: 26 September 2014 / Accepted: 21 November 2014 / Published: 25 December 2014
(This article belongs to the Special Issue Antimicrobial Peptides)
View Full-Text   |   Download PDF [1887 KB, uploaded 25 December 2014]   |  


Cationic antimicrobial peptides (CAMPs) are important innate immune defenses that inhibit colonization by pathogens and contribute to clearance of infections. Gram-negative bacterial pathogens are a major target, yet many of them have evolved mechanisms to resist these antimicrobials. These resistance mechanisms can be critical contributors to bacterial virulence and are often crucial for survival within the host. Here, we summarize methods used by Gram-negative bacteria to resist CAMPs. Understanding these mechanisms may lead to new therapeutic strategies against pathogens with extensive CAMP resistance. View Full-Text
Keywords: antimicrobial peptide; AMP; CAMP; antibiotic resistance; Gram-negative antimicrobial peptide; AMP; CAMP; antibiotic resistance; Gram-negative

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Band, V.I.; Weiss, D.S. Mechanisms of Antimicrobial Peptide Resistance in Gram-Negative Bacteria. Antibiotics 2015, 4, 18-41.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Antibiotics EISSN 2079-6382 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top