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Antibiotics 2015, 4(1), 18-41; doi:10.3390/antibiotics4010018

Mechanisms of Antimicrobial Peptide Resistance in Gram-Negative Bacteria

1,2,3
and
2,3,4,*
1
Department of Microbiology and Immunology, Emory University, Atlanta, GA 30329, USA
2
Yerkes Primate Research Center, Emory University, Atlanta, GA 30329, USA
3
Emory Vaccine Center, Emory University, Atlanta, GA 30329, USA
4
Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30329, USA
*
Author to whom correspondence should be addressed.
Academic Editor: William M. Shafer
Received: 26 September 2014 / Accepted: 21 November 2014 / Published: 25 December 2014
(This article belongs to the Special Issue Antimicrobial Peptides)
View Full-Text   |   Download PDF [1887 KB, uploaded 25 December 2014]   |  

Abstract

Cationic antimicrobial peptides (CAMPs) are important innate immune defenses that inhibit colonization by pathogens and contribute to clearance of infections. Gram-negative bacterial pathogens are a major target, yet many of them have evolved mechanisms to resist these antimicrobials. These resistance mechanisms can be critical contributors to bacterial virulence and are often crucial for survival within the host. Here, we summarize methods used by Gram-negative bacteria to resist CAMPs. Understanding these mechanisms may lead to new therapeutic strategies against pathogens with extensive CAMP resistance. View Full-Text
Keywords: antimicrobial peptide; AMP; CAMP; antibiotic resistance; Gram-negative antimicrobial peptide; AMP; CAMP; antibiotic resistance; Gram-negative
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Band, V.I.; Weiss, D.S. Mechanisms of Antimicrobial Peptide Resistance in Gram-Negative Bacteria. Antibiotics 2015, 4, 18-41.

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