Next Article in Journal
Mechanisms of Antimicrobial Peptide Resistance in Gram-Negative Bacteria
Previous Article in Journal
Structure-Dependent Immune Modulatory Activity of Protegrin-1 Analogs
Article Menu

Export Article

Open AccessReview
Antibiotics 2015, 4(1), 1-17; doi:10.3390/antibiotics4010001

The Role of Antifungals against Candida Biofilm in Catheter-Related Candidemia

1
Department of Clinical Microbiology and Infectious Diseases, Gregorio Marañón Hospital, Madrid 28007, Spain
2
Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid 28040, Spain
3
CIBER de Enfermedades Respiratorias (CIBER RES), CB06/06/0058, Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Christopher C. Butler
Received: 11 October 2014 / Accepted: 9 December 2014 / Published: 25 December 2014
View Full-Text   |   Download PDF [634 KB, uploaded 25 December 2014]

Abstract

Catheter-related bloodstream infection (C-RBSI) is one of the most frequent nosocomial infections. It is associated with high rates of morbidity and mortality. Candida spp. is the third most common cause of C-RBSI after coagulase-negative staphylococci and Staphylococcus aureus and is responsible for approximately 8% of episodes. The main cause of catheter-related candidemia is the ability of some Candida strains—mainly C. albicans and C. parapsilosis—to produce biofilms. Many in vitro and in vivo models have been designed to assess the activity of antifungal drugs against Candida biofilms. Echinocandins have proven to be the most active antifungal drugs. Potential options in situations where the catheter cannot be removed include the combination of systemic and lock antifungal therapy. However, well-designed and -executed clinical trials must be performed before firm recommendations can be issued. View Full-Text
Keywords: biofilm; Candida; antifungals; catheter-related candidemia biofilm; Candida; antifungals; catheter-related candidemia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Bouza, E.; Guinea, J.; Guembe, M. The Role of Antifungals against Candida Biofilm in Catheter-Related Candidemia. Antibiotics 2015, 4, 1-17.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antibiotics EISSN 2079-6382 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top