The Role of Cationic Polypeptides in Modulating HIV-1 Infection of the Cervicovaginal Mucosa
AbstractThe mucosa and overlying fluid of the female reproductive tract (FRT) are portals for the heterosexual transmission of HIV-1. Toward the ongoing development of topically applied microbicides and mucosal vaccines against HIV-1, it is evermore important to understand how the dynamic FRT mucosa is involved in controlling transmission and infection of HIV-1. Cationic peptides and proteins are the principal innate immune effector molecules of mucosal surfaces, and interact in a combinatorial fashion to modulate HIV-1 infection of the cervix and vagina. While cationic peptides and proteins have historically been categorized as antimicrobial or have other host-benefitting roles, an increasing number of these molecules have been found to augment HIV-1 infection and potentially antagonize host defense. Complex environmental factors such as hormonal fluctuations and/or bacterial and viral co-infections provide additional challenges to both experimentation and interpretation of results. In the context of heterosexual transmission of HIV-1, this review explores how various cationic peptides and proteins participate in modulating host defense against HIV-1 of the cervicovaginal mucosa. View Full-Text
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Cole, A.L.; Cole, A.M. The Role of Cationic Polypeptides in Modulating HIV-1 Infection of the Cervicovaginal Mucosa. Antibiotics 2014, 3, 677-693.
Cole AL, Cole AM. The Role of Cationic Polypeptides in Modulating HIV-1 Infection of the Cervicovaginal Mucosa. Antibiotics. 2014; 3(4):677-693.Chicago/Turabian Style
Cole, Amy L.; Cole, Alexander M. 2014. "The Role of Cationic Polypeptides in Modulating HIV-1 Infection of the Cervicovaginal Mucosa." Antibiotics 3, no. 4: 677-693.