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Antibiotics 2014, 3(3), 317-340; doi:10.3390/antibiotics3030317

Drug Resistance Mechanisms in Mycobacterium tuberculosis

*  and
Laboratory of Microbiology, Department of Biochemistry and Microbiology, Ghent University, K.L. Ledeganckstraat 35, 9000 Gent, Belgium
* Author to whom correspondence should be addressed.
Received: 8 April 2014 / Revised: 20 June 2014 / Accepted: 23 June 2014 / Published: 2 July 2014
(This article belongs to the Special Issue Mechanisms of Antibiotic Resistance)
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Tuberculosis (TB) is a serious public health problem worldwide. Its situation is worsened by the presence of multidrug resistant (MDR) strains of Mycobacterium tuberculosis, the causative agent of the disease. In recent years, even more serious forms of drug resistance have been reported. A better knowledge of the mechanisms of drug resistance of M. tuberculosis and the relevant molecular mechanisms involved will improve the available techniques for rapid drug resistance detection and will help to explore new targets for drug activity and development. This review article discusses the mechanisms of action of anti-tuberculosis drugs and the molecular basis of drug resistance in M. tuberculosis.
Keywords: drug resistance; molecular mechanisms; Mycobacterium tuberculosis drug resistance; molecular mechanisms; Mycobacterium tuberculosis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Palomino, J.C.; Martin, A. Drug Resistance Mechanisms in Mycobacterium tuberculosis. Antibiotics 2014, 3, 317-340.

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