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Antibiotics 2014, 3(2), 174-192; doi:10.3390/antibiotics3020174

Antimicrobial Stewardship and Urinary Tract Infections

Department of Medicine, Division of Infectious Diseases, University of Miami Miller School of Medicine, 1120 NW 14th Street, Suite 851, Miami, FL 33136, USA
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Received: 14 March 2014 / Revised: 10 April 2014 / Accepted: 21 April 2014 / Published: 5 May 2014
(This article belongs to the Special Issue Antibiotics and Urinary Tract Infections)
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Abstract

Urinary tract infections are the most common bacterial infections encountered in ambulatory and long-term care settings in the United States. Urine samples are the largest single category of specimens received by most microbiology laboratories and many such cultures are collected from patients who have no or questionable urinary symptoms. Unfortunately, antimicrobials are often prescribed inappropriately in such patients. Antimicrobial use, whether appropriate or inappropriate, is associated with the selection for antimicrobial-resistant organisms colonizing or infecting the urinary tract. Infections caused by antimicrobial-resistant organisms are associated with higher rates of treatment failures, prolonged hospitalizations, increased costs and mortality. Antimicrobial stewardship consists of avoidance of antimicrobials when appropriate and, when antimicrobials are indicated, use of strategies to optimize the selection, dosing, route of administration, duration and timing of antimicrobial therapy to maximize clinical cure while limiting the unintended consequences of antimicrobial use, including toxicity and selection of resistant microorganisms. This article reviews successful antimicrobial stewardship strategies in the diagnosis and treatment of urinary tract infections. View Full-Text
Keywords: antimicrobial stewardship; antimicrobial resistance; UTI; urinary tract infections; antibiotics; duration; appropriate antimicrobial stewardship; antimicrobial resistance; UTI; urinary tract infections; antibiotics; duration; appropriate
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Abbo, L.M.; Hooton, T.M. Antimicrobial Stewardship and Urinary Tract Infections. Antibiotics 2014, 3, 174-192.

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