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Antibiotics 2014, 3(2), 163-173; doi:10.3390/antibiotics3020163
Article

Adult and Pediatric Intra-Institutional Trends of Ciprofloxacin Susceptibility in E. coli Positive Urinary Cultures

1
, 2
 and 1,*
Received: 13 February 2014; in revised form: 3 April 2014 / Accepted: 4 April 2014 / Published: 21 April 2014
(This article belongs to the Special Issue Antibiotics and Urinary Tract Infections)
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Abstract: Antimicrobial drug resistance in treatment of urinary tract infection (UTI) continues to rise worldwide. To examine contributions of physician prescribing patterns to fluoroquinolone (ciprofloxacin, CP) resistance, we examined Escherichia coli (E. coli) resistance patterns in urinary cultures. Since CP usage is limited in children, we compared CP resistance trends in adults and children to those of more commonly used trimethoprim-sulfamethoxazole (TMP-SMX) and nitrofurantoin (NF). Our data show that although the general pediatric population has lower resistance to ciprofloxacin, resistance levels are rising with increased usage. While NF susceptibility is historically stable, TMP-SMX resistance is slightly higher in children compared to adults. In both adults and children, antimicrobial resistance patterns vary according to clinical practice site, with ambulatory urology patients showing the highest resistance. This suggests that physician’s prescribing patterns contribute to antimicrobial resistance.
Keywords: ciprofloxacin; trimethoprim-sulfamethoxazole; nitrofurantoin; susceptibility; bacterial resistance; E. coli; urinary cultures; urinary tract infection ciprofloxacin; trimethoprim-sulfamethoxazole; nitrofurantoin; susceptibility; bacterial resistance; E. coli; urinary cultures; urinary tract infection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Owumi, W.; Banaei, N.; Shortliffe, L.D. Adult and Pediatric Intra-Institutional Trends of Ciprofloxacin Susceptibility in E. coli Positive Urinary Cultures. Antibiotics 2014, 3, 163-173.

AMA Style

Owumi W, Banaei N, Shortliffe LD. Adult and Pediatric Intra-Institutional Trends of Ciprofloxacin Susceptibility in E. coli Positive Urinary Cultures. Antibiotics. 2014; 3(2):163-173.

Chicago/Turabian Style

Owumi, Winifred; Banaei, Niaz; Shortliffe, Linda D. 2014. "Adult and Pediatric Intra-Institutional Trends of Ciprofloxacin Susceptibility in E. coli Positive Urinary Cultures." Antibiotics 3, no. 2: 163-173.


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