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Antibiotics 2014, 3(2), 193-215; doi:10.3390/antibiotics3020193
Review

β-Lactam Antibiotics Renaissance

1
, 1,*  and 2,*
Received: 5 March 2014; in revised form: 30 April 2014 / Accepted: 4 May 2014 / Published: 9 May 2014
(This article belongs to the Special Issue Mechanisms of Antibiotic Resistance)
Download PDF [1041 KB, uploaded 9 May 2014]
Abstract: Since the 1940s β-lactam antibiotics have been used to treat bacterial infections. However, emergence and dissemination of β-lactam resistance has reached the point where many marketed β-lactams no longer are clinically effective. The increasing prevalence of multidrug-resistant bacteria and the progressive withdrawal of pharmaceutical companies from antibiotic research have evoked a strong reaction from health authorities, who have implemented initiatives to encourage the discovery of new antibacterials. Despite this gloomy scenario, several novel β-lactam antibiotics and β-lactamase inhibitors have recently progressed into clinical trials, and many more such compounds are being investigated. Here we seek to provide highlights of recent developments relating to the discovery of novel β-lactam antibiotics and β-lactamase inhibitors.
Keywords: β-lactam antibiotics; β-lactamase inhibitors; bacterial infections β-lactam antibiotics; β-lactamase inhibitors; bacterial infections
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Qin, W.; Panunzio, M.; Biondi, S. β-Lactam Antibiotics Renaissance. Antibiotics 2014, 3, 193-215.

AMA Style

Qin W, Panunzio M, Biondi S. β-Lactam Antibiotics Renaissance. Antibiotics. 2014; 3(2):193-215.

Chicago/Turabian Style

Qin, Wenling; Panunzio, Mauro; Biondi, Stefano. 2014. "β-Lactam Antibiotics Renaissance." Antibiotics 3, no. 2: 193-215.

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