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Antibiotics 2013, 2(1), 100-114; doi:10.3390/antibiotics2010100

Bacterial Responses and Genome Instability Induced by Subinhibitory Concentrations of Antibiotics

Faculté de Médecine Paris Descartes, 24 rue du Faubourg Saint-Jacques, INSERM U1001, Université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France
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Received: 8 February 2013 / Revised: 4 March 2013 / Accepted: 5 March 2013 / Published: 14 March 2013
(This article belongs to the Special Issue Antibiotic Resistance)
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Abstract

Nowadays, the emergence and spread of antibiotic resistance have become an utmost medical and economical problem. It has also become evident that subinhibitory concentrations of antibiotics, which pollute all kind of terrestrial and aquatic environments, have a non-negligible effect on the evolution of antibiotic resistance in bacterial populations. Subinhibitory concentrations of antibiotics have a strong effect on mutation rates, horizontal gene transfer and biofilm formation, which may all contribute to the emergence and spread of antibiotic resistance. Therefore, the molecular mechanisms and the evolutionary pressures shaping the bacterial responses to subinhibitory concentrations of antibiotics merit to be extensively studied. Such knowledge is valuable for the development of strategies to increase the efficacy of antibiotic treatments and to extend the lifetime of antibiotics used in therapy by slowing down the emergence of antibiotic resistance.
Keywords: antibiotics; resistance; stress response; mutagenesis antibiotics; resistance; stress response; mutagenesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Laureti, L.; Matic, I.; Gutierrez, A. Bacterial Responses and Genome Instability Induced by Subinhibitory Concentrations of Antibiotics. Antibiotics 2013, 2, 100-114.

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