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Biosensors 2018, 8(2), 55; https://doi.org/10.3390/bios8020055

Biosensors for Non-Invasive Detection of Celiac Disease Biomarkers in Body Fluids

1
Department of Chemistry, School of Sciences, College of Engineering, Science & Technology (CEST), Fiji National University, P.O. Box 7222, Nasinu, Fiji
2
Institute of Chemistry, Faculty of Science, ELTE Eötvös Loránd University, Pázmány P. sétány 1/A, H-1117 Budapest, Hungary
*
Author to whom correspondence should be addressed.
Received: 12 May 2018 / Revised: 13 June 2018 / Accepted: 15 June 2018 / Published: 16 June 2018
(This article belongs to the Special Issue Biomarkers)
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Abstract

Celiac disease is a chronic gluten-initiated autoimmune disorder that predominantly damages the mucosa of the small intestine in genetically-susceptible individuals. It affects a large and increasing number of the world’s population. The diagnosis of this disease and monitoring the response of patients to the therapy, which is currently a life-long gluten-free diet, require the application of reliable, rapid, sensitive, selective, simple, and cost-effective analytical tools. Celiac disease biomarker detection in full blood, serum, or plasma offers a non-invasive way to do this and is well-suited to being the first step of diagnosis. Biosensors provide a novel and alternative way to perform conventional techniques in biomarker sensing, in which electrode material and architecture play important roles in achieving sensitive, selective, and stable detection. There are many opportunities to build and modify biosensor platforms using various materials and detection methods, and the aim of the present review is to summarize developments in this field. View Full-Text
Keywords: celiac disease; gluten; biomarkers; biosensors; anti-gliadin; anti-deamidated gliadin; anti-transglutaminase; HLA alleles celiac disease; gluten; biomarkers; biosensors; anti-gliadin; anti-deamidated gliadin; anti-transglutaminase; HLA alleles
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Pasinszki, T.; Krebsz, M. Biosensors for Non-Invasive Detection of Celiac Disease Biomarkers in Body Fluids. Biosensors 2018, 8, 55.

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