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Biosensors 2018, 8(3), 67; https://doi.org/10.3390/bios8030067

Autoantibodies as Potential Biomarkers in Breast Cancer

Department of Biomedical Engineering, University of Houston, 3517 Cullen BLVD, SERC 2008, Houston, TX 77204, USA
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Author to whom correspondence should be addressed.
Received: 14 June 2018 / Revised: 11 July 2018 / Accepted: 11 July 2018 / Published: 13 July 2018
(This article belongs to the Special Issue Biomarkers)
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Abstract

Breast cancer is a major cause of mortality in women; however, technologies for early stage screening and diagnosis (e.g., mammography and other imaging technologies) are not optimal for the accurate detection of cancer. This creates demand for a more effective diagnostic means to replace or be complementary to existing technologies for early discovery of breast cancer. Cancer neoantigens could reflect tumorigenesis, but they are hardly detectable at the early stage. Autoantibodies, however, are biologically amplified and hence may be measurable early on, making them promising biomarkers to discriminate breast cancer from healthy tissue accurately. In this review, we summarized the recent findings of breast cancer specific antigens and autoantibodies, which may be useful in early detection, disease stratification, and monitoring of treatment responses of breast cancer. View Full-Text
Keywords: autoantibody; breast cancer; early diagnosis; immunotherapy autoantibody; breast cancer; early diagnosis; immunotherapy
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Qiu, J.; Keyser, B.; Lin, Z.-T.; Wu, T. Autoantibodies as Potential Biomarkers in Breast Cancer. Biosensors 2018, 8, 67.

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