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Nanomaterials 2017, 7(9), 276; doi:10.3390/nano7090276

Preparation, Characterization, and Preliminary In Vitro Testing of Nanoceria-Loaded Liposomes

1
Smart Bio-Interfaces, Istituto Italiano di Tecnologia, Viale Rinaldo Piaggio 34, 56025 Pontedera, Italy
2
Research Organization for Nano & Life innovation, Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, 162-8480 Tokyo, Japan
3
The Biorobotics Institute, Scuola Superiore Sant’Anna, Viale Rinaldo Piaggio 34, 56025 Pontedera, Italy
4
Electron Microscopy Facility, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy
5
Materials Characterization Facility, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy
6
Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering (TWIns), Waseda University, 2-2 Wakamatsu-cho, Shinjuku-ku, 162-8480 Tokyo, Japan
7
Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy
*
Authors to whom correspondence should be addressed.
Received: 4 August 2017 / Revised: 13 September 2017 / Accepted: 14 September 2017 / Published: 16 September 2017
(This article belongs to the Special Issue Nanocolloids for Nanomedicine and Drug delivery)
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Abstract

Cerium oxide nanoparticles (nanoceria), well known for their pro- and antioxidant features, have been recently proposed for the treatment of several pathologies, including cancer and neurodegenerative diseases. However, interaction between nanoceria and biological molecules such as proteins and lipids, short blood circulation time, and the need of a targeted delivery to desired sites are some aspects that require strong attention for further progresses in the clinical application of these nanoparticles. The aim of this work is the encapsulation of nanoceria into a liposomal formulation in order to improve their therapeutic potentialities. After the preparation through a reverse-phase evaporation method, size, Z-potential, morphology, and loading efficiency of nanoceria-loaded liposomes were investigated. Finally, preliminary in vitro studies were performed to test cell uptake efficiency and preserved antioxidant activity. Nanoceria-loaded liposomes showed a good colloidal stability, an excellent biocompatibility, and strong antioxidant properties due to the unaltered activity of the entrapped nanoceria. With these results, the possibility of exploiting liposomes as carriers for cerium oxide nanoparticles is demonstrated here for the first time, thus opening exciting new opportunities for in vivo applications. View Full-Text
Keywords: cerium oxide nanoparticles; liposomes; drug delivery cerium oxide nanoparticles; liposomes; drug delivery
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MDPI and ACS Style

Grillone, A.; Li, T.; Battaglini, M.; Scarpellini, A.; Prato, M.; Takeoka, S.; Ciofani, G. Preparation, Characterization, and Preliminary In Vitro Testing of Nanoceria-Loaded Liposomes. Nanomaterials 2017, 7, 276.

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