Special Issue "Nanocolloids for Nanomedicine and Drug delivery"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 30 April 2018

Special Issue Editor

Guest Editor
Prof. Stefano Leporatti

CNR Nanotec-Istituto di Nanotecnologia, Via Monteroni, c/o Campus Ekotecne, 73100 Lecce (LE), Italy
Website | E-Mail
Phone: +39-083-231-9829
Interests: nanomedicine; cytomechanics; drug delivery; scanning force microscopy; polymer nanocapsules; halloysite clay nanotubes; drug nanocolloids; nano-micelles

Special Issue Information

Dear Colleagues,

This Special Issue of Nanomaterials, “Nanocolloids for Nanomedicine and Drug Delivery”, focuses on new development of tailored nano-systems for targeted drug delivery.

Nanomedicine is an interdisciplinary field where nanotechnology, nanoscience and nanoengineering interact with life sciences. It is expected to lead to the development of novel nanosystems, drugs and other applications for diagnosis and therapy. Furthermore nanoparticulates drug delivery are new attractive vehicles for transport and release drug on a targeted site.

This Special Issue will highlight on novel nanocolloids like magnetic nanoparticles, nanomicelles, nanoliposomes, nanocapsules and nanoclays, stimulating novel interests and ideas in research groups involved in the development of novel nanotools within the different areas of nanomaterials. The publication of original articles will contribute to the scientific progress in the area of personalized medicine and further stimulate the entering into clinical praxis of such new nanosystems.

  • Nanocolloids
  • Nanomedicine
  • Nanoclays
  • Nanoliposomes
  • Nanomicelles
  • Nanocapsules
  • Drug Delivery

Prof. Stefano Leporatti
Guest Editor

Manuscript Submission Information

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Published Papers (3 papers)

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Research

Open AccessArticle Preparation, Characterization, and Preliminary In Vitro Testing of Nanoceria-Loaded Liposomes
Nanomaterials 2017, 7(9), 276; doi:10.3390/nano7090276
Received: 4 August 2017 / Revised: 13 September 2017 / Accepted: 14 September 2017 / Published: 16 September 2017
PDF Full-text (1676 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Cerium oxide nanoparticles (nanoceria), well known for their pro- and antioxidant features, have been recently proposed for the treatment of several pathologies, including cancer and neurodegenerative diseases. However, interaction between nanoceria and biological molecules such as proteins and lipids, short blood circulation time,
[...] Read more.
Cerium oxide nanoparticles (nanoceria), well known for their pro- and antioxidant features, have been recently proposed for the treatment of several pathologies, including cancer and neurodegenerative diseases. However, interaction between nanoceria and biological molecules such as proteins and lipids, short blood circulation time, and the need of a targeted delivery to desired sites are some aspects that require strong attention for further progresses in the clinical application of these nanoparticles. The aim of this work is the encapsulation of nanoceria into a liposomal formulation in order to improve their therapeutic potentialities. After the preparation through a reverse-phase evaporation method, size, Z-potential, morphology, and loading efficiency of nanoceria-loaded liposomes were investigated. Finally, preliminary in vitro studies were performed to test cell uptake efficiency and preserved antioxidant activity. Nanoceria-loaded liposomes showed a good colloidal stability, an excellent biocompatibility, and strong antioxidant properties due to the unaltered activity of the entrapped nanoceria. With these results, the possibility of exploiting liposomes as carriers for cerium oxide nanoparticles is demonstrated here for the first time, thus opening exciting new opportunities for in vivo applications. Full article
(This article belongs to the Special Issue Nanocolloids for Nanomedicine and Drug delivery)
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Figure 1

Open AccessArticle Gadolinium-Doped Gallic Acid-Zinc/Aluminium-Layered Double Hydroxide/Gold Theranostic Nanoparticles for a Bimodal Magnetic Resonance Imaging and Drug Delivery System
Nanomaterials 2017, 7(9), 244; doi:10.3390/nano7090244
Received: 16 July 2017 / Revised: 18 August 2017 / Accepted: 25 August 2017 / Published: 31 August 2017
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Abstract
We have developed gadolinium-based theranostic nanoparticles for co-delivery of drug and magnetic resonance imaging (MRI) contrast agent using Zn/Al-layered double hydroxide as the nanocarrier platform, a naturally occurring phenolic compound, gallic acid (GA) as therapeutic agent, and Gd(NO3)3 as diagnostic
[...] Read more.
We have developed gadolinium-based theranostic nanoparticles for co-delivery of drug and magnetic resonance imaging (MRI) contrast agent using Zn/Al-layered double hydroxide as the nanocarrier platform, a naturally occurring phenolic compound, gallic acid (GA) as therapeutic agent, and Gd(NO3)3 as diagnostic agent. Gold nanoparticles (AuNPs) were grown on the system to support the contrast for MRI imaging. The nanoparticles were characterized using techniques such as Hi-TEM, XRD, ICP-ES. Kinetic release study of the GA from the nanoparticles showed about 70% of GA was released over a period of 72 h. The in vitro cell viability test for the nanoparticles showed relatively low toxicity to human cell lines (3T3) and improved toxicity on cancerous cell lines (HepG2). A preliminary contrast property test of the nanoparticles, tested on a 3 Tesla MRI machine at various concentrations of GAGZAu and water (as a reference) indicates that the nanoparticles have a promising dual diagnostic and therapeutic features to further develop a better future for clinical remedy for cancer treatment. Full article
(This article belongs to the Special Issue Nanocolloids for Nanomedicine and Drug delivery)
Figures

Open AccessArticle High Ultraviolet Absorption in Colloidal Gallium Nanoparticles Prepared from Thermal Evaporation
Nanomaterials 2017, 7(7), 172; doi:10.3390/nano7070172
Received: 9 June 2017 / Revised: 26 June 2017 / Accepted: 30 June 2017 / Published: 6 July 2017
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Abstract
New methods for the production of colloidal Ga nanoparticles (GaNPs) are introduced based on the evaporation of gallium on expendable aluminum zinc oxide (AZO) layer. The nanoparticles can be prepared in aqueous or organic solvents such as tetrahydrofuran in order to be used
[...] Read more.
New methods for the production of colloidal Ga nanoparticles (GaNPs) are introduced based on the evaporation of gallium on expendable aluminum zinc oxide (AZO) layer. The nanoparticles can be prepared in aqueous or organic solvents such as tetrahydrofuran in order to be used in different sensing applications. The particles had a quasi mono-modal distribution with diameters ranging from 10 nm to 80 nm, and their aggregation status depended on the solvent nature. Compared to common chemical synthesis, our method assures higher yield with the possibility of tailoring particles size by adjusting the deposition time. The GaNPs have been studied by spectrophotometry to obtain the absorption spectra. The colloidal solutions exhibit strong plasmonic absorption in the ultra violet (UV) region around 280 nm, whose width and intensity mainly depend on the nanoparticles dimensions and their aggregation state. With regard to the colloidal GaNPs flocculate behavior, the water solvent case has been investigated for different pH values, showing UV-visible absorption because of the formation of NPs clusters. Using discrete dipole approximation (DDA) method simulations, a close connection between the UV absorption and NPs with a diameter smaller than ~40 nm was observed. Full article
(This article belongs to the Special Issue Nanocolloids for Nanomedicine and Drug delivery)
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Figure 1

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