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Nanomaterials 2017, 7(3), 56; doi:10.3390/nano7030056

In Vitro Comparative Skin Irritation Induced by Nano and Non-Nano Zinc Oxide

Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Av. Joan XXIII 27-31, Barcelona 08028, Spain
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Academic Editor: Eleonore Fröhlich
Received: 26 October 2016 / Revised: 25 January 2017 / Accepted: 28 February 2017 / Published: 4 March 2017
(This article belongs to the Special Issue Cytotoxicity of Nanoparticles)
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Abstract

This study was designed to determine whether nano-sized ZnO has the potential to cause acute cutaneous irritation using cultured HaCaT keratinocytes and a human skin equivalent as in vitro models, compared to non-nanomaterials. Commercial nano ZnO with different sizes (50 nm and 100 nm) was characterized by dynamic light scattering (DLS) and microscopy (SEM) in different media. Nano ZnO reduced the cell viability of HaCaT in a dose-dependent and time-dependent manner, in a similar way to macro ZnO. However, the 3D-epidermis model revealed no irritation at 1 mg/mL after 24 h of exposure. In conclusion, nano-sized ZnO does not irritate skin, in a similar manner to non-nano ZnO. View Full-Text
Keywords: zinc oxide; skin irritation; cytotoxicity; keratinocytes; 3D-epidermal model zinc oxide; skin irritation; cytotoxicity; keratinocytes; 3D-epidermal model
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Vinardell, M.P.; Llanas, H.; Marics, L.; Mitjans, M. In Vitro Comparative Skin Irritation Induced by Nano and Non-Nano Zinc Oxide. Nanomaterials 2017, 7, 56.

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