Special Issue "Cytotoxicity of Nanoparticles"
A special issue of Nanomaterials (ISSN 2079-4991).
Deadline for manuscript submissions: closed (20 October 2016)
Prof. Dr. Eleonore Fröhlich
Center for Medical Research, Medical University of Graz, Stiftingtalstr 24, Graz A-8010, Austria
Website | E-Mail
Interests: biological and toxicological evaluation of nanoparticles; development of physiologically relevant in-vitro models; cytotoxicity of Nanoparticles
Human exposure to nanomaterials is not restricted to a specific group of individuals, but affects the entire population because nanoparticles are present in the environment, integrated in food and consumer products, and present in the workplace. Depending on the type of exposure (dermal, respiratory, oral, intravenous, etc.) physicochemical properties of the particles, including protein corona formation and particle concentrations, that reach viable cells, differ. Particle characterization in the respective biological fluids, relevant exposure conditions, and cellular models and appropriate readout parameters are, therefore, of key importance for the physiological relevance of cytotoxicity testing.
This Special Issue focuses on the adverse cellular effects of nanoparticles, including particle changes in biological fluids, permeation across barriers, cellular interaction, cell uptake and mechanisms of cellular action in conventional and advanced culture models.
Prof. Dr. Eleonore Fröhlich
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- cellular mechanisms
- 3D culture
- gene regulation
- signaling pathways
- cellular uptake
- oxidative stress
- protein corona
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Authors: Hisao Haniu*
Abstract: We are currently studying the medical application of carbon nanotubes (CNTs), a major nanomaterial used in biomaterials. However, the evaluation of CNT safety remains difficult and without consensus. Moreover, multi-walled CNTs (MWCNTs), which can become tangled in the manufacturing process, are also challenging to assess for safety since they do not readily disperse. In this report, we succeeded in dispersing previously tangled MWCNTs following treatment with a new type of sonicator (PR-1 Nano Premixer; Thinky). The untangled MWCNTs dispersed fully and produced a different result on cytotoxicity than did conventionally sonicated tangled MWCNTs. We describe the effects of the two dispersion methods on the size of MWCNTs and their resulting cytotoxicity.