Cytotoxic Induction and Photoacoustic Imaging of Breast Cancer Cells Using Astaxanthin-Reduced Gold Nanoparticles
AbstractAstaxanthin, a kind of photosynthetic pigment, was employed for gold nanoparticle formation. Nanoparticles were characterized using Ulteraviolet-Visible (UV-Vis) spectroscopy, transmission electron microscopy, and X-ray diffraction, and the possible presence of astaxanthin functional groups were analyzed by Fourier transform infrared spectroscopy (FTIR). The cytotoxic effect of synthesized nanoparticles was evaluated against MDA-MB-231 (human breast cancer cells) using a tetrazolium-based assay, and synthesized nanoparticles exhibited dose-dependent toxicity. The morphology upon cell death was differentiated through fluorescent microscopy using different stains that predicted apoptosis. The synthesized nanoparticles were applied in ultrasound-coupled photoacoustic imaging to obtain good images of treated cells. Astaxanthin-reduced gold nanoparticle has the potential to act as a promising agent in the field of photo-based diagnosis and therapy. View Full-Text
Share & Cite This Article
Bharathiraja, S.; Manivasagan, P.; Quang Bui, N.; Oh, Y.-O.; Lim, I.G.; Park, S.; Oh, J. Cytotoxic Induction and Photoacoustic Imaging of Breast Cancer Cells Using Astaxanthin-Reduced Gold Nanoparticles. Nanomaterials 2016, 6, 78.
Bharathiraja S, Manivasagan P, Quang Bui N, Oh Y-O, Lim IG, Park S, Oh J. Cytotoxic Induction and Photoacoustic Imaging of Breast Cancer Cells Using Astaxanthin-Reduced Gold Nanoparticles. Nanomaterials. 2016; 6(4):78.Chicago/Turabian Style
Bharathiraja, Subramaniyan; Manivasagan, Panchanathan; Quang Bui, Nhat; Oh, Yun-Ok; Lim, In G.; Park, Suhyun; Oh, Junghwan. 2016. "Cytotoxic Induction and Photoacoustic Imaging of Breast Cancer Cells Using Astaxanthin-Reduced Gold Nanoparticles." Nanomaterials 6, no. 4: 78.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.