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Nanomaterials 2016, 6(4), 65; doi:10.3390/nano6040065

Facile Synthesis of Gd-Functionalized Gold Nanoclusters as Potential MRI/CT Contrast Agents

1,†
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1,†
,
1
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1
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1,2,* and 1,3,*
1
The Institute for Translational Nanomedicine, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200120, China
2
State Key Lab of Silicon Materials, Zhejiang University, Hangzhou 310027, China
3
Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 28780, USA
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Yurii Gun’ko
Received: 4 February 2016 / Revised: 28 March 2016 / Accepted: 28 March 2016 / Published: 9 April 2016
(This article belongs to the Special Issue Nanoparticles in Bioimaging)
View Full-Text   |   Download PDF [1756 KB, uploaded 9 April 2016]   |  

Abstract

Multi-modal imaging plays a key role in the earlier detection of disease. In this work, a facile bioinspired method was developed to synthesize Gd-functionalized gold nanoclusters (Gd-Au NCs). The Gd-Au NCs exhibit a uniform size, with an average size of 5.6 nm in dynamic light scattering (DLS), which is a bit bigger than gold clusters (3.74 nm, DLS), while the fluorescent properties of Gd-Au NCs are almost the same as that of Au NCs. Moreover, the Gd-Au NCs exhibit a high longitudinal relaxivity value (r1) of 22.111 s−1 per mM of Gd in phosphate-buffered saline (PBS), which is six times higher than that of commercial Magnevist (A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid, Gd-DTPA, r1 = 3.56 mM−1·s−1). Besides, as evaluated by nano single photon emission computed tomography (SPECT) and computed tomography (CT) the Gd-Au NCs have a potential application as CT contrast agents because of the Au element. Finally, the Gd-Au NCs show little cytotoxicity, even when the Au concentration is up to 250 μM. Thus, the Gd-Au NCs can act as multi-modal imaging contrast agents. View Full-Text
Keywords: gold nanocluster; bovine serum albumin; contrast agent; magnetic resonance imaging; computed tomography gold nanocluster; bovine serum albumin; contrast agent; magnetic resonance imaging; computed tomography
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Le, W.; Cui, S.; Chen, X.; Zhu, H.; Chen, B.; Cui, Z. Facile Synthesis of Gd-Functionalized Gold Nanoclusters as Potential MRI/CT Contrast Agents. Nanomaterials 2016, 6, 65.

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