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Nanomaterials 2016, 6(12), 229; doi:10.3390/nano6120229

The Assembly of DNA Amphiphiles at Liquid Crystal-Aqueous Interface

Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China
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Academic Editors: Leonid Gurevich and John H. T. Luong
Received: 30 June 2016 / Revised: 19 October 2016 / Accepted: 17 November 2016 / Published: 1 December 2016
(This article belongs to the Special Issue DNA-Based Nanotechnology)
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Abstract

In this article, we synthesized a type of DNA amphiphiles (called DNA-lipids) and systematically studied its assembly behavior at the liquid crystal (LC)—aqueous interface. It turned out that the pure DNA-lipids at various concentrations cannot trigger the optical transition of liquid crystals from planar anchoring to homeotropic anchoring at the liquid crystal—aqueous interface. The co-assembly of DNA-lipid and l-dilauroyl phosphatidylcholine (l-DLPC) indicated that the DLPC assembled all over the LC-aqueous interface, and DNA-lipids prefer to couple with LC in certain areas, particularly in polarized and fluorescent image, forming micron sized net-like structures. The addition of DNA complementary to DNA-lipids forming double stranded DNA-lipids caused de-assembly of DNA-lipids from LC-aqueous interface, resulting in the disappearance of net-like structures, which can be visualized through polarized microscope. The optical changes combined with DNA unique designable property and specific interaction with wide range of target molecules, the DNA-lipids decorated LC-aqueous interface would provide a new platform for biological sensing and diagnosis. View Full-Text
Keywords: liquid crystal; interface; self-assembly; DNA amphiphiles; detection liquid crystal; interface; self-assembly; DNA amphiphiles; detection
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhou, J.; Dong, Y.; Zhang, Y.; Liu, D.; Yang, Z. The Assembly of DNA Amphiphiles at Liquid Crystal-Aqueous Interface. Nanomaterials 2016, 6, 229.

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