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Nanomaterials 2016, 6(1), 3; doi:10.3390/nano6010003

Receptor-Mediated Drug Delivery Systems Targeting to Glioma

Department of Pharmaceutics, School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai 201203, China
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Author to whom correspondence should be addressed.
Academic Editors: Subramanian Tamil Selvan, Wolfgang J. Parak and Pablo del Pino
Received: 25 September 2015 / Revised: 8 November 2015 / Accepted: 24 November 2015 / Published: 28 December 2015
(This article belongs to the Special Issue Nanoparticles in Theranostics)
View Full-Text   |   Download PDF [889 KB, uploaded 28 December 2015]   |  

Abstract

Glioma has been considered to be the most frequent primary tumor within the central nervous system (CNS). The complexity of glioma, especially the existence of the blood-brain barrier (BBB), makes the survival and prognosis of glioma remain poor even after a standard treatment based on surgery, radiotherapy, and chemotherapy. This provides a rationale for the development of some novel therapeutic strategies. Among them, receptor-mediated drug delivery is a specific pattern taking advantage of differential expression of receptors between tumors and normal tissues. The strategy can actively transport drugs, such as small molecular drugs, gene medicines, and therapeutic proteins to glioma while minimizing adverse reactions. This review will summarize recent progress on receptor-mediated drug delivery systems targeting to glioma, and conclude the challenges and prospects of receptor-mediated glioma-targeted therapy for future applications. View Full-Text
Keywords: glioma; blood-brain barrier (BBB); receptor-mediated; single ligand-modified targeting systems; dual ligand-modified targeting systems glioma; blood-brain barrier (BBB); receptor-mediated; single ligand-modified targeting systems; dual ligand-modified targeting systems
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wang, S.; Meng, Y.; Li, C.; Qian, M.; Huang, R. Receptor-Mediated Drug Delivery Systems Targeting to Glioma. Nanomaterials 2016, 6, 3.

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