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Nanomaterials 2015, 5(4), 2302-2316; doi:10.3390/nano5042302

Mesoporous Silica Nanoparticles Loaded with Cisplatin and Phthalocyanine for Combination Chemotherapy and Photodynamic Therapy in vitro

1
Department of Chemistry, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
2
Center for Biomedical Engineering and Science, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Subramanian Tamil Selvan
Received: 7 October 2015 / Revised: 3 December 2015 / Accepted: 10 December 2015 / Published: 16 December 2015
(This article belongs to the Special Issue Nanoparticles in Theranostics)
View Full-Text   |   Download PDF [1862 KB, uploaded 16 December 2015]   |  

Abstract

Mesoporous silica nanoparticles (MSNs) have been synthesized and loaded with both aluminum chloride phthalocyanine (AlClPc) and cisplatin as combinatorial therapeutics for treating cancer. The structural and photophysical properties of the MSN materials were characterized by different spectroscopic and microscopic techniques. Intracellular uptake and cytotoxicity were evaluated in human cervical cancer (HeLa) cells by confocal laser scanning microscopy (CLSM) and 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assays, respectively. The CLSM experiments showed that the MSN materials can be readily internalized in HeLa cells. The cytotoxic experiments demonstrated that, after light exposure, the combination of both AlClPc and cisplatin compounds in the same MSN platform potentiate the toxic effect against HeLa cells in comparison to the control AlClPc-MSN and cisplatin-MSN materials. These results show the potential of using MSN platforms as nanocarriers for combination photodynamic and chemotherapies to treat cancer. View Full-Text
Keywords: mesoporous silica nanoparticles; photodynamic therapy; chemotherapy; cisplatin; phototoxicity; phthalocyanine; fluorescent imaging mesoporous silica nanoparticles; photodynamic therapy; chemotherapy; cisplatin; phototoxicity; phthalocyanine; fluorescent imaging
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Vivero-Escoto, J.L.; Elnagheeb, M. Mesoporous Silica Nanoparticles Loaded with Cisplatin and Phthalocyanine for Combination Chemotherapy and Photodynamic Therapy in vitro. Nanomaterials 2015, 5, 2302-2316.

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