Next Article in Journal / Special Issue
Penetration and Toxicity of Nanomaterials in Higher Plants
Previous Article in Journal
Graphene Oxide Synthesis from Agro Waste
Previous Article in Special Issue
Modeling the Dispersibility of Single Walled Carbon Nanotubes in Organic Solvents by Quantitative Structure-Activity Relationship Approach
Article Menu

Export Article

Open AccessArticle
Nanomaterials 2015, 5(2), 835-850; doi:10.3390/nano5020835

Toxicity and Biokinetics of Colloidal Gold Nanoparticles

1
Department of Food Science and Technology, Seoul Women's University, 621 Hwarang-ro, Nowon-gu, Seoul 139-774, Korea
2
SMNANOBIO Co., Ltd., 160 Techno 2-ro, Yuseong-gu, Daejeon 305-500, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Robert Tanguay
Received: 9 April 2015 / Revised: 7 May 2015 / Accepted: 13 May 2015 / Published: 21 May 2015
(This article belongs to the Special Issue Advancements in Nanotoxicology)
View Full-Text   |   Download PDF [1420 KB, uploaded 21 May 2015]   |  

Abstract

Gold nanoparticles (Au-NPs) have promising potential for diverse biological application, but it has not been completely determined whether Au-NP has potential toxicity in vitro and in vivo. In the present study, toxicity of Au-NP was evaluated in human intestinal cells as well as in rats after 14-day repeated oral administration. Biokinetic study was also performed to assess oral absorption and tissue distribution. The results demonstrated that Au-NP did not cause cytotoxic effects on cells after 24 h exposure in terms of inhibition of cell proliferation, membrane damage, and oxidative stress. However, when a small number of cells were exposed to Au-NP for seven days, colony forming ability remarkably decreased by Au-NP treatment, suggesting its potential toxicity after long-term exposure at high concentration. Biokinetic study revealed that Au-NP slowly entered the blood stream and slightly accumulated only in kidney after oral administration to rats. Whereas, orally administered Au ions were rapidly absorbed, and then distributed in kidney, liver, lung, and spleen at high levels, suggesting that the biological fate of Au-NP is primarily in nanoparticulate form, not in ionic Au. Fourteen-day repeated oral toxicity evaluation showed that Au-NP did not cause severe toxicity in rats based on histopathological, hematological, and serum biochemical analysis. View Full-Text
Keywords: gold nanoparticle; cytotoxicity; oral absorption; tissue distribution; oral toxicity gold nanoparticle; cytotoxicity; oral absorption; tissue distribution; oral toxicity
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Jo, M.-R.; Bae, S.-H.; Go, M.-R.; Kim, H.-J.; Hwang, Y.-G.; Choi, S.-J. Toxicity and Biokinetics of Colloidal Gold Nanoparticles. Nanomaterials 2015, 5, 835-850.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nanomaterials EISSN 2079-4991 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top