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J. Funct. Biomater. 2017, 8(1), 4; doi:10.3390/jfb8010004

Bioactive Polymeric Materials for Tissue Repair

1
Volpe Research Center, ADA Foundation, Gaithersburg, MD 20899, USA
2
Food and Drug Administration, Silver Spring, MD 20993, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Francesco Puoci
Received: 10 November 2016 / Revised: 10 January 2017 / Accepted: 18 January 2017 / Published: 26 January 2017
(This article belongs to the Special Issue Journal of Functional Biomaterials: Feature Papers 2016)
View Full-Text   |   Download PDF [4061 KB, uploaded 13 February 2017]   |  

Abstract

Bioactive polymeric materials based on calcium phosphates have tremendous appeal for hard tissue repair because of their well-documented biocompatibility. Amorphous calcium phosphate (ACP)-based ones additionally protect against unwanted demineralization and actively support regeneration of hard tissue minerals. Our group has been investigating the structure/composition/property relationships of ACP polymeric composites for the last two decades. Here, we present ACP’s dispersion in a polymer matrix and the fine-tuning of the resin affects the physicochemical, mechanical, and biological properties of ACP polymeric composites. These studies illustrate how the filler/resin interface and monomer/polymer molecular structure affect the material’s critical properties, such as ion release and mechanical strength. We also present evidence of the remineralization efficacy of ACP composites when exposed to accelerated acidic challenges representative of oral environment conditions. The utility of ACP has recently been extended to include airbrushing as a platform technology for fabrication of nanofiber scaffolds. These studies, focused on assessing the feasibility of incorporating ACP into various polymer fibers, also included the release kinetics of bioactive calcium and phosphate ions from nanofibers and evaluate the biorelevance of the polymeric ACP fiber networks. We also discuss the potential for future integration of the existing ACP scaffolds into therapeutic delivery systems used in the precision medicine field. View Full-Text
Keywords: airbrushing; blow spinning; amorphous calcium phosphate; bone repair; cell/fiber interactions; nanofibers; remineralizing polymeric composite airbrushing; blow spinning; amorphous calcium phosphate; bone repair; cell/fiber interactions; nanofibers; remineralizing polymeric composite
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Bienek, D.R.; Tutak, W.; Skrtic, D. Bioactive Polymeric Materials for Tissue Repair. J. Funct. Biomater. 2017, 8, 4.

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J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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