Next Article in Journal / Special Issue
Aloe Vera for Tissue Engineering Applications
Previous Article in Journal
The Anti-Inflammatory and Vasodilating Effects of Three Selected Dietary Organic Sulfur Compounds from Allium Species
Previous Article in Special Issue
Bioactive Polymeric Materials for Tissue Repair
Article Menu

Export Article

Open AccessArticle
J. Funct. Biomater. 2017, 8(1), 7; doi:10.3390/jfb8010007

Atomic Force Microscopy: A Powerful Tool to Address Scaffold Design in Tissue Engineering

1
Faculty of Sciences, Biophotonics and Medical Imaging group and Laser Lab, VU University Amsterdam, De Boelelaan 1081 HV Amsterdam, The Netherlands
2
Institute of Polymers, Composites and Biomaterials, National Research Council of Italy, V.le Kennedy 54, Pad 20, Mostra d’Oltremare, Naples 80125, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Francesco Puoci
Received: 4 November 2016 / Revised: 7 February 2017 / Accepted: 8 February 2017 / Published: 13 February 2017
(This article belongs to the Special Issue Journal of Functional Biomaterials: Feature Papers 2016)
View Full-Text   |   Download PDF [1210 KB, uploaded 13 February 2017]   |  

Abstract

Functional polymers currently represent a basic component of a large range of biological and biomedical applications including molecular release, tissue engineering, bio-sensing and medical imaging. Advancements in these fields are driven by the use of a wide set of biodegradable polymers with controlled physical and bio-interactive properties. In this context, microscopy techniques such as Atomic Force Microscopy (AFM) are emerging as fundamental tools to deeply investigate morphology and structural properties at micro and sub-micrometric scale, in order to evaluate the in time relationship between physicochemical properties of biomaterials and biological response. In particular, AFM is not only a mere tool for screening surface topography, but may offer a significant contribution to understand surface and interface properties, thus concurring to the optimization of biomaterials performance, processes, physical and chemical properties at the micro and nanoscale. This is possible by capitalizing the recent discoveries in nanotechnologies applied to soft matter such as atomic force spectroscopy to measure surface forces through force curves. By tip-sample local interactions, several information can be collected such as elasticity, viscoelasticity, surface charge densities and wettability. This paper overviews recent developments in AFM technology and imaging techniques by remarking differences in operational modes, the implementation of advanced tools and their current application in biomaterials science, in terms of characterization of polymeric devices in different forms (i.e., fibres, films or particles). View Full-Text
Keywords: Atomic Force Microscopy (AFM); conductive AFM; thermal analysis; phase imaging; nano-indentation; force spectroscopy; electrospun fibres; films; micro/nano particles Atomic Force Microscopy (AFM); conductive AFM; thermal analysis; phase imaging; nano-indentation; force spectroscopy; electrospun fibres; films; micro/nano particles
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Marrese, M.; Guarino, V.; Ambrosio, L. Atomic Force Microscopy: A Powerful Tool to Address Scaffold Design in Tissue Engineering. J. Funct. Biomater. 2017, 8, 7.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top