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J. Funct. Biomater. 2017, 8(1), 5; doi:10.3390/jfb8010005

The Anti-Inflammatory and Vasodilating Effects of Three Selected Dietary Organic Sulfur Compounds from Allium Species

1
Department of Anesthesiology, Chi-Mei Medical Center, Tainan 71004, Taiwan
2
Department of Recreation and Health-Care Management, Chi-Mei Medical Center, Tainan 71004, Taiwan
3
Division of Cardiology, Chi-Mei Medical Center, Tainan 71004, Taiwan
4
Center of General Education, Chi-Mei Medical Center, Tainan 71004, Taiwan
5
Department of Food Science and Technology, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Joachim B. Kohn
Received: 18 May 2016 / Revised: 21 December 2016 / Accepted: 21 January 2017 / Published: 26 January 2017
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Abstract

The anti-inflammatory and vasodilating effects of three selected dietary organic sulfur compounds (OSC), including diallyl disulfide (DADS), dimethyl disulfide (DMDS), and propyl disulfide (PDS), from Allium species were investigated. In the anti-inflammatory activity assay, the three OSC demonstrated significant inhibition of nitric oxide (NO) and prostaglandin E2 (PGE2) production in LPS-induced RAW 264.7 cells. The expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) in activated RAW 264.7 cells was inhibited by the three OSC, indicating that the three OSC prevented the LPS-induced inflammatory response in RAW 264.7 cells. For the vasodilative assay, the three OSC were ineffective in producing NO in SVEC4-10 cells, but they did enhance prostacyclin (PGI2) production. The expression of COX-2 in SVEC4-10 cells was activated by DADS and DMDS. Pretreatment of SVEC4-10 cells with the three OSC decreased ROS generation in H2O2-induced SVEC4-10 cells. In addition, the three OSC significantly inhibited angiotensin-I converting enzyme (ACE). The up-regulation of PGI2 production and COX-2 expression by DADS and DMDS and the reduction of ROS generation by DADS, DMDS, and PDS in SVEC4-10 cells contributed to the vasodilative effect of the three OSC. Collectively, these findings suggest that DADS, DMDS, and PDS are potential anti-inflammatory and vasodilative mediators. View Full-Text
Keywords: angiotensin-converting enzyme; anti-inflammatory activity; diallyl disulfide; dimethyl disulfide; propyl disulfide; prostacyclin; vasodilation angiotensin-converting enzyme; anti-inflammatory activity; diallyl disulfide; dimethyl disulfide; propyl disulfide; prostacyclin; vasodilation
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MDPI and ACS Style

Chu, C.-C.; Wu, W.-S.; Shieh, J.-P.; Chu, H.-L.; Lee, C.-P.; Duh, P.-D. The Anti-Inflammatory and Vasodilating Effects of Three Selected Dietary Organic Sulfur Compounds from Allium Species. J. Funct. Biomater. 2017, 8, 5.

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