Comparison of the Pharmacokinetic Properties of Hemoglobin-Based Oxygen Carriers
AbstractHemoglobin (Hb) is an ideal material for use in the development of an oxygen carrier in view of its innate biological properties. However, the vascular retention of free Hb is too short to permit a full therapeutic effect because Hb is rapidly cleared from the kidney via glomerular filtration or from the liver via the haptogloblin-CD 163 pathway when free Hb is administered in the blood circulation. Attempts have been made to develop alternate acellular and cellular types of Hb based oxygen carriers (HBOCs), in which Hb is processed via various routes in order to regulate its pharmacokinetic properties. These HBOCs have been demonstrated to have superior pharmacokinetic properties including a longer half-life than the Hb molecule in preclinical and clinical trials. The present review summarizes and compares the pharmacokinetic properties of acellular and cellular type HBOCs that have been developed through different approaches, such as polymerization, PEGylation, cross-linking, and encapsulation. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Taguchi, K.; Yamasaki, K.; Maruyama, T.; Otagiri, M. Comparison of the Pharmacokinetic Properties of Hemoglobin-Based Oxygen Carriers. J. Funct. Biomater. 2017, 8, 11.
Taguchi K, Yamasaki K, Maruyama T, Otagiri M. Comparison of the Pharmacokinetic Properties of Hemoglobin-Based Oxygen Carriers. Journal of Functional Biomaterials. 2017; 8(1):11.Chicago/Turabian Style
Taguchi, Kazuaki; Yamasaki, Keishi; Maruyama, Toru; Otagiri, Masaki. 2017. "Comparison of the Pharmacokinetic Properties of Hemoglobin-Based Oxygen Carriers." J. Funct. Biomater. 8, no. 1: 11.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.