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J. Funct. Biomater. 2017, 8(1), 10; doi:10.3390/jfb8010010

Overview of Potential Clinical Applications of Hemoglobin Vesicles (HbV) as Artificial Red Cells, Evidenced by Preclinical Studies of the Academic Research Consortium

Department of Chemistry, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan
Academic Editor: Francesco Puoci
Received: 30 January 2017 / Revised: 2 March 2017 / Accepted: 10 March 2017 / Published: 15 March 2017
(This article belongs to the Special Issue Blood Substitutes: Evolution and Future Applications)
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Abstract

Hemoglobin (Hb) is the most abundant protein in whole blood. This fact implies that the oxygen binding and releasing function of Hb is the most vital for sustaining life. All Hb is compartmentalized in red blood cells (RBCs) with corpuscular Hb concentration of about 35 g/dL, covered with a thin biomembrane. In spite of its abundance, Hb sometimes shows toxicity once it is leaked from RBCs. The shielding effect of the RBC membrane is physiologically important. Based on this structural importance, we have studied artificial red cells (Hb vesicles, HbV) as artificial oxygen carriers, which encapsulate a purified and concentrated Hb solution in phospholipid vesicles, mimicking the cellular structure of RBCs. Our academic research consortium has clarified the safety and efficacy of this HbV, aiming at clinical applications. Because of some superior characteristics to those of RBCs, HbV has the potential for use not only as a transfusion alternative but also for oxygen and carbon monoxide therapeutics, perfusate for transplant organs, and photosensitizer. In this review paper, such potential applications are summarized. View Full-Text
Keywords: blood substitutes; artificial red cells; oxygen carriers; hemoglobin; liposomes; hemoglobin (Hb)-based oxygen carriers (HBOCs); resuscitative fluid; organ perfusate; carbon monoxide; photosensitizer blood substitutes; artificial red cells; oxygen carriers; hemoglobin; liposomes; hemoglobin (Hb)-based oxygen carriers (HBOCs); resuscitative fluid; organ perfusate; carbon monoxide; photosensitizer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sakai, H. Overview of Potential Clinical Applications of Hemoglobin Vesicles (HbV) as Artificial Red Cells, Evidenced by Preclinical Studies of the Academic Research Consortium. J. Funct. Biomater. 2017, 8, 10.

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