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J. Funct. Biomater. 2017, 8(2), 14; doi:10.3390/jfb8020014

Artificial Red Blood Cells as Potential Photosensitizers in Dye Laser Treatment Against Port-Wine Stains

1
Chiba Rosai Hospital, 1-16 Tatsumidaihigashi, Ichihara, Chiba 290003, Japan
2
Saitama Children’s Medical Center, 1-2 Shintoshin Chuo-ku Saitama, Saitama 330877, Japan
3
The Laboratory of Pathology, Hatano Research Institute, Food and Drug Safety Center, 729-5 Ochiai Hatano, Kanagawa 2578523, Japan
4
Department of Chemistry, Nara Medical University, 840 Shijo-cho, Kashihara 6340813, Japan
*
Authors to whom correspondence should be addressed.
Academic Editor: Carmen Alvarez-Lorenzo
Received: 2 March 2017 / Revised: 29 March 2017 / Accepted: 10 April 2017 / Published: 13 April 2017
(This article belongs to the Special Issue Blood Substitutes: Evolution and Future Applications)
View Full-Text   |   Download PDF [2279 KB, uploaded 18 April 2017]   |  

Abstract

We suggest a novel method that uses artificial blood cells (hemoglobin vesicles, Hb-Vs) as photosensitizers in dye laser treatment (at 595-nm wavelength) for port-wine stains (i.e., capillary malformations presenting as red birthmarks) based on the results of animal experiments. As compared with human red blood cells, Hb-Vs have the same absorbance of 595 nm wavelength light and produce the same level of heat following dye laser irradiation. Small sized Hb-Vs (250 nm) distribute in the plasma phase in blood and tend to flow in the marginal zone of microvessels. Intravenous injections of Hb-Vs caused the dilatation of microvessels, and dye laser treatment with Hb-Vs destroyed the vessel wall effectively. Following the intravenous injection of Hb-Vs, the microvessels contained more Hb that absorbed laser photons and produced heat. This extra Hb tended to flow near the endothelial cells, which were the target of the laser treatment. These attributes of Hb-Vs will potentially contribute to enhancing the efficacy of dye laser treatment for port-wine stains. Hemoglobin is a type of porphyrin. Thus, our proposed treatment may have aspects of photodynamic therapy using porphyrin that leads to a cytotoxicity effect by active oxygen. View Full-Text
Keywords: artificial blood cells; hemoglobin vesicle; capillary malformation; port-wine stain; laser treatment; light therapy equipment; photosensitizer; chromophore artificial blood cells; hemoglobin vesicle; capillary malformation; port-wine stain; laser treatment; light therapy equipment; photosensitizer; chromophore
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Rikihisa, N.; Watanabe, S.; Saito, Y.; Sakai, H. Artificial Red Blood Cells as Potential Photosensitizers in Dye Laser Treatment Against Port-Wine Stains. J. Funct. Biomater. 2017, 8, 14.

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