Peptide Amphiphiles in Corneal Tissue Engineering
AbstractThe increasing interest in effort towards creating alternative therapies have led to exciting breakthroughs in the attempt to bio-fabricate and engineer live tissues. This has been particularly evident in the development of new approaches applied to reconstruct corneal tissue. The need for tissue-engineered corneas is largely a response to the shortage of donor tissue and the lack of suitable alternative biological scaffolds preventing the treatment of millions of blind people worldwide. This review is focused on recent developments in corneal tissue engineering, specifically on the use of self-assembling peptide amphiphiles for this purpose. Recently, peptide amphiphiles have generated great interest as therapeutic molecules, both in vitro and in vivo. Here we introduce this rapidly developing field, and examine innovative applications of peptide amphiphiles to create natural bio-prosthetic corneal tissue in vitro. The advantages of peptide amphiphiles over other biomaterials, namely their wide range of functions and applications, versatility, and transferability are also discussed to better understand how these fascinating molecules can help solve current challenges in corneal regeneration. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Miotto, M.; Gouveia, R.M.; Connon, C.J. Peptide Amphiphiles in Corneal Tissue Engineering. J. Funct. Biomater. 2015, 6, 687-707.
Miotto M, Gouveia RM, Connon CJ. Peptide Amphiphiles in Corneal Tissue Engineering. Journal of Functional Biomaterials. 2015; 6(3):687-707.Chicago/Turabian Style
Miotto, Martina; Gouveia, Ricardo M.; Connon, Che J. 2015. "Peptide Amphiphiles in Corneal Tissue Engineering." J. Funct. Biomater. 6, no. 3: 687-707.