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J. Funct. Biomater. 2015, 6(3), 708-832; doi:10.3390/jfb6030708

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Kudrinskaja sq. 1-155, Moscow 123242, Russia
Academic Editor: Francesco Puoci
Received: 16 June 2015 / Revised: 31 July 2015 / Accepted: 1 August 2015 / Published: 7 August 2015
View Full-Text   |   Download PDF [2545 KB, uploaded 7 August 2015]   |  

Abstract

The state-of-the-art on calcium orthophosphate (CaPO4)-containing biocomposites and hybrid biomaterials suitable for biomedical applications is presented. Since these types of biomaterials offer many significant and exciting possibilities for hard tissue regeneration, this subject belongs to a rapidly expanding area of biomedical research. Through the successful combinations of the desired properties of matrix materials with those of fillers (in such systems, CaPO4 might play either role), innovative bone graft biomaterials can be designed. Various types of CaPO4-based biocomposites and hybrid biomaterials those are either already in use or being investigated for biomedical applications are extensively discussed. Many different formulations in terms of the material constituents, fabrication technologies, structural and bioactive properties, as well as both in vitro and in vivo characteristics have been already proposed. Among the others, the nano-structurally controlled biocomposites, those containing nanodimensional compounds, biomimetically fabricated formulations with collagen, chitin and/or gelatin, as well as various functionally graded structures seem to be the most promising candidates for clinical applications. The specific advantages of using CaPO4-based biocomposites and hybrid biomaterials in the selected applications are highlighted. As the way from a laboratory to a hospital is a long one and the prospective biomedical candidates have to meet many different necessities, the critical issues and scientific challenges that require further research and development are also examined. View Full-Text
Keywords: calcium orthophosphates; hydroxyapatite; biocomposites; hybrid biomaterials; bone grafts; biomedical applications; tissue engineering calcium orthophosphates; hydroxyapatite; biocomposites; hybrid biomaterials; bone grafts; biomedical applications; tissue engineering
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Dorozhkin, S.V. Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications. J. Funct. Biomater. 2015, 6, 708-832.

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