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J. Funct. Biomater. 2015, 6(3), 650-666; doi:10.3390/jfb6030650

Intraocular Implants for the Treatment of Autoimmune Uveitis

Department of Ophthalmology/Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, 608 Stanton L. Young Blvd, DMEI PA404, Oklahoma City, OK 73104, USA
Academic Editor: Dimitrios Karamichos
Received: 29 June 2015 / Revised: 21 July 2015 / Accepted: 27 July 2015 / Published: 31 July 2015
(This article belongs to the Special Issue Ocular Tissue Engineering)
View Full-Text   |   Download PDF [212 KB, uploaded 31 July 2015]

Abstract

Uveitis is the third leading cause of blindness in developed countries. Currently, the most widely used treatment of non-infectious uveitis is corticosteroids. Posterior uveitis and macular edema can be treated with intraocular injection of corticosteroids, however, this is problematic in chronic cases because of the need for repeat injections. Another option is systemic immunosuppressive therapies that have their own undesirable side effects. These systemic therapies result in a widespread suppression of the entire immune system, leaving the patient susceptible to infection. Therefore, an effective localized treatment option is preferred. With the recent advances in bioengineering, biodegradable polymers that allow for a slow sustained-release of a medication. These advances have culminated in drug delivery implants that are food and drug administration (FDA) approved for the treatment of non-infectious uveitis. In this review, we discuss the types of ocular implants available and some of the polymers used, implants used for the treatment of non-infectious uveitis, and bioengineered alternatives that are on the horizon. View Full-Text
Keywords: uveitis; non-infectious uveitis; intraocular implant; uveitis treatment; ocular drug delivery device uveitis; non-infectious uveitis; intraocular implant; uveitis treatment; ocular drug delivery device
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lee, D.J. Intraocular Implants for the Treatment of Autoimmune Uveitis. J. Funct. Biomater. 2015, 6, 650-666.

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