J. Funct. Biomater. 2013, 4(3), 89-113; doi:10.3390/jfb4030089
Article

Preliminary Investigation of the Dissolution Behavior, Cytocompatibility, Effects of Fibrinogen Conformation and Platelet Adhesion for Radiopaque Embolic Particles

Received: 11 January 2013; in revised form: 6 May 2013 / Accepted: 8 June 2013 / Published: 10 July 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Experimental embolic particles based on a novel zinc-silicate glass system have been biologically evaluated for potential consideration in transcatheter arterial embolization procedures. In addition to controlling the cytotoxicity and haemocompatibility for such embolic particles, its glass structure may mediate specific responses via dissolution in the physiological environment. In a 120 h in-vitro dissolution study, ion release levels for silicon (Si4+), sodium (Na+), calcium (Ca2+), zinc (Zn2+), titanium (Ti4+), lanthanum (La3+), strontium (Sr2+), and magnesium (Mg2+), were found to range from 0.04 to 5.41 ppm, 0.27–2.28 ppm, 2.32–8.47 ppm, 0.16–0.20 ppm, 0.12–2.15 ppm, 0.16–0.49 ppm and 0.01–0.12 ppm, respectively for the series of glass compositions evaluated. Initial release of Zn2+ (1.93–10.40 ppm) was only evident after 120 h. All compositions showed levels of cell viabilities ranging from 61.31 ± 4.33% to 153.7 ± 1.25% at 25%–100% serial extract dilutions. The conformational state of fibrinogen, known to induce thrombi, indicated that no changes were induced with respect of the materials dissolution by-products. Furthermore, the best-in-class experimental composition showed equivalency to contour PVA in terms of inducing platelet adhesion. The data generated here provides requisite evidence to continue to in-vivo pre-clinical evaluation using the best-in-class experimental composition evaluated.
Keywords: embolic particle; dissolution; cytotoxicity; fibrinogen conformation; platelet adhesion
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MDPI and ACS Style

Kehoe, S.; Tremblay, M.-L.; Coughlan, A.; Towler, M.R.; Rainey, J.K.; Abraham, R.J.; Boyd, D. Preliminary Investigation of the Dissolution Behavior, Cytocompatibility, Effects of Fibrinogen Conformation and Platelet Adhesion for Radiopaque Embolic Particles. J. Funct. Biomater. 2013, 4, 89-113.

AMA Style

Kehoe S, Tremblay M-L, Coughlan A, Towler MR, Rainey JK, Abraham RJ, Boyd D. Preliminary Investigation of the Dissolution Behavior, Cytocompatibility, Effects of Fibrinogen Conformation and Platelet Adhesion for Radiopaque Embolic Particles. Journal of Functional Biomaterials. 2013; 4(3):89-113.

Chicago/Turabian Style

Kehoe, Sharon; Tremblay, Marie-Laurence; Coughlan, Aisling; Towler, Mark R.; Rainey, Jan K.; Abraham, Robert J.; Boyd, Daniel. 2013. "Preliminary Investigation of the Dissolution Behavior, Cytocompatibility, Effects of Fibrinogen Conformation and Platelet Adhesion for Radiopaque Embolic Particles." J. Funct. Biomater. 4, no. 3: 89-113.

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