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J. Funct. Biomater. 2012, 3(2), 283-297; doi:10.3390/jfb3020283
Article

Hemocompatibility of Inorganic Physical Vapor Deposition (PVD) Coatings on Thermoplastic Polyurethane Polymers

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Received: 9 March 2012 / Revised: 10 April 2012 / Accepted: 11 April 2012 / Published: 17 April 2012
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Abstract

Biocompatibility improvements for blood contacting materials are of increasing interest for implanted devices and interventional tools. The current study focuses on inorganic (titanium, titanium nitride, titanium oxide) as well as diamond-like carbon (DLC) coating materials on polymer surfaces (thermoplastic polyurethane), deposited by magnetron sputtering und pulsed laser deposition at room temperature. DLC was used pure (a-C:H) as well as doped with silicon, titanium, and nitrogen + titanium (a-C:H:Si, a-C:H:Ti, a-C:H:N:Ti). In-vitro testing of the hemocompatibility requires mandatory dynamic test conditions to simulate in-vivo conditions, e.g., realized by a cone-and-plate analyzer. In such tests, titanium- and nitrogen-doped DLC and titanium nitride were found to be optimally anti-thrombotic and better than state-of-the-art polyurethane polymers. This is mainly due to the low tendency to platelet microparticle formation, a high content of remaining platelets in the whole blood after testing and low concentration of platelet activation and aggregation markers. Comparing this result to shear-flow induced cell motility tests with e.g., Dictostelium discoideum cell model organism reveals similar tendencies for the investigated materials.
Keywords: inorganic thin film materials; diamond-like carbon; dynamic blood testing; blood inorganic thin film materials; diamond-like carbon; dynamic blood testing; blood
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lackner, J.M.; Waldhauser, W.; Hartmann, P.; Bruckert, F.; Weidenhaupt, M.; Major, R.; Sanak, M.; Wiesinger, M.; Heim, D. Hemocompatibility of Inorganic Physical Vapor Deposition (PVD) Coatings on Thermoplastic Polyurethane Polymers. J. Funct. Biomater. 2012, 3, 283-297.

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