Next Article in Journal
Increasing the Detection Limit of the Parkinson Disorder through a Specific Surface Chemistry Applied onto Inner Surface of the Titration Well
Next Article in Special Issue
Characterization of Porous TiO2 Surfaces Formed on 316L Stainless Steel by Plasma Electrolytic Oxidation for Stent Applications
Previous Article in Journal
Quercetin-Imprinted Nanospheres as Novel Drug Delivery Devices
J. Funct. Biomater. 2012, 3(2), 283-297; doi:10.3390/jfb3020283
Article

Hemocompatibility of Inorganic Physical Vapor Deposition (PVD) Coatings on Thermoplastic Polyurethane Polymers

1,* , 1
,
1
,
2
,
2
,
3
,
4
,
5
 and
5
1 Joanneum Research Forschungsges.m.b.H., Institute for Surface Technologies and Photonics, Functional Surfaces, Leobner Straße 94, Niklasdorf A-8712, Austria 2 Grenoble Institute of Technology, Parvis Louis Néel, 38000 Grenoble Cedex 9, France 3 Institute of Metallurgy and Materials Sciences, Polish Academy of Sciences, Reymonta 25, Krakow 30-059, Poland 4 Department of Medicine, Jagiellonian University Medical College, Kopernika 23, Kraków 31-501, Poland 5 Faculty of Technical and Environmental Sciences, University of Applied Sciences Upper Austria, Franz-Fritsch-Straße 11, Wels 4600, Austria
* Author to whom correspondence should be addressed.
Received: 9 March 2012 / Revised: 10 April 2012 / Accepted: 11 April 2012 / Published: 17 April 2012
View Full-Text   |   Download PDF [902 KB, uploaded 17 April 2012]   |   Browse Figures
SciFeed

Abstract

Biocompatibility improvements for blood contacting materials are of increasing interest for implanted devices and interventional tools. The current study focuses on inorganic (titanium, titanium nitride, titanium oxide) as well as diamond-like carbon (DLC) coating materials on polymer surfaces (thermoplastic polyurethane), deposited by magnetron sputtering und pulsed laser deposition at room temperature. DLC was used pure (a-C:H) as well as doped with silicon, titanium, and nitrogen + titanium (a-C:H:Si, a-C:H:Ti, a-C:H:N:Ti). In-vitro testing of the hemocompatibility requires mandatory dynamic test conditions to simulate in-vivo conditions, e.g., realized by a cone-and-plate analyzer. In such tests, titanium- and nitrogen-doped DLC and titanium nitride were found to be optimally anti-thrombotic and better than state-of-the-art polyurethane polymers. This is mainly due to the low tendency to platelet microparticle formation, a high content of remaining platelets in the whole blood after testing and low concentration of platelet activation and aggregation markers. Comparing this result to shear-flow induced cell motility tests with e.g., Dictostelium discoideum cell model organism reveals similar tendencies for the investigated materials.
Keywords: inorganic thin film materials; diamond-like carbon; dynamic blood testing; blood inorganic thin film materials; diamond-like carbon; dynamic blood testing; blood
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Lackner, J.M.; Waldhauser, W.; Hartmann, P.; Bruckert, F.; Weidenhaupt, M.; Major, R.; Sanak, M.; Wiesinger, M.; Heim, D. Hemocompatibility of Inorganic Physical Vapor Deposition (PVD) Coatings on Thermoplastic Polyurethane Polymers. J. Funct. Biomater. 2012, 3, 283-297.

View more citation formats

Related Articles

Article Metrics

Comments

[Return to top]
J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert