Abstract: To develop a novel ablation therapy for human solid cancer, the heating properties of a ferromagnetic carbon steel rod and a prototype Ti-coated needle using this carbon steel rod, were investigated in several high-frequency outputs at 300 kHz. In the former, the heating property was drastically different among the three inclination angles (θ = 0°, 45° and 90°) relative to the magnetic flux direction as a result of the shape magnetic anisotropy. However, the effect of the inclination angles was completely eliminated in the latter. It is considered that the complete non-oriented heating property relative to the magnetic flux direction allows the precise control of the ablation temperature during minimally invasive thermotherapy without a lead-wire connected to a fiber-optic thermometer. This newly designed Ti-coated device will be suitable for clinical use combined with its superior biocompatibility for ablation treatments using high-frequency induction heating.
Keywords: cancer therapy; ablation treatment; high-frequency induction heating; AC magnetic field; shape magnetic anisotropy; magnetic flux direction; biocompatibility
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Naohara, T.; Aono, H.; Maehara, T.; Hirazawa, H.; Matsutomo, S.; Watanabe, Y. Development of Ti-Coated Ferromagnetic Needle, Adaptable for Ablation Cancer Therapy by High-Frequency Induction Heating. J. Funct. Biomater. 2012, 3, 163-172.
Naohara T, Aono H, Maehara T, Hirazawa H, Matsutomo S, Watanabe Y. Development of Ti-Coated Ferromagnetic Needle, Adaptable for Ablation Cancer Therapy by High-Frequency Induction Heating. Journal of Functional Biomaterials. 2012; 3(1):163-172.
Naohara, Takashi; Aono, Hiromichi; Maehara, Tsunehiro; Hirazawa, Hideyuki; Matsutomo, Shinya; Watanabe, Yuji. 2012. "Development of Ti-Coated Ferromagnetic Needle, Adaptable for Ablation Cancer Therapy by High-Frequency Induction Heating." J. Funct. Biomater. 3, no. 1: 163-172.