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Computational Study of pH-sensitive Hydrogel-based Microfluidic Flow Controllers
Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, 117576 Singapore
Department of Chemical and Bio-Molecular Engineering, National University of Singapore, 5 Engineering Drive 2, 117576 Singapore
Mineral, Metal and Material Technology Centre, National University of Singapore, 9 Engineering Drive 1, 117576 Singapore
* Author to whom correspondence should be addressed.
Received: 13 July 2011; in revised form: 10 August 2011 / Accepted: 22 August 2011 / Published: 25 August 2011
Abstract: This computational study investigates the sensing and actuating behavior of a pH-sensitive hydrogel-based microfluidic flow controller. This hydrogel-based flow controller has inherent advantage in its unique stimuli-sensitive properties, removing the need for an external power supply. The predicted swelling behavior the hydrogel is validated with steady-state and transient experiments. We then demonstrate how the model is implemented to study the sensing and actuating behavior of hydrogels for different microfluidic flow channel/hydrogel configurations: e.g., for flow in a T-junction with single and multiple hydrogels. In short, the results suggest that the response of the hydrogel-based flow controller is slow. Therefore, two strategies to improve the response rate of the hydrogels are proposed and demonstrated. Finally, we highlight that the model can be extended to include other stimuli-responsive hydrogels such as thermo-, electric-, and glucose-sensitive hydrogels.
Keywords: flow control; hydrogel; mathematical model; microchannel; microfluidic; pH; simulation
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Kurnia, J.C.; Birgersson, E.; Mujumdar, A.S. Computational Study of pH-sensitive Hydrogel-based Microfluidic Flow Controllers. J. Funct. Biomater. 2011, 2, 195-212.
Kurnia JC, Birgersson E, Mujumdar AS. Computational Study of pH-sensitive Hydrogel-based Microfluidic Flow Controllers. Journal of Functional Biomaterials. 2011; 2(3):195-212.
Kurnia, Jundika C.; Birgersson, Erik; Mujumdar, Arun S. 2011. "Computational Study of pH-sensitive Hydrogel-based Microfluidic Flow Controllers." J. Funct. Biomater. 2, no. 3: 195-212.