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J. Funct. Biomater. 2011, 2(3), 195-212; doi:10.3390/jfb2030195
Article

Computational Study of pH-sensitive Hydrogel-based Microfluidic Flow Controllers

1
, 2,*  and 1,3
Received: 13 July 2011; in revised form: 10 August 2011 / Accepted: 22 August 2011 / Published: 25 August 2011
(This article belongs to the Special Issue Stimuli Responsive Biomaterials)
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Abstract: This computational study investigates the sensing and actuating behavior of a pH-sensitive hydrogel-based microfluidic flow controller. This hydrogel-based flow controller has inherent advantage in its unique stimuli-sensitive properties, removing the need for an external power supply. The predicted swelling behavior the hydrogel is validated with steady-state and transient experiments. We then demonstrate how the model is implemented to study the sensing and actuating behavior of hydrogels for different microfluidic flow channel/hydrogel configurations: e.g., for flow in a T-junction with single and multiple hydrogels. In short, the results suggest that the response of the hydrogel-based flow controller is slow. Therefore, two strategies to improve the response rate of the hydrogels are proposed and demonstrated. Finally, we highlight that the model can be extended to include other stimuli-responsive hydrogels such as thermo-, electric-, and glucose-sensitive hydrogels.
Keywords: flow control; hydrogel; mathematical model; microchannel; microfluidic; pH; simulation flow control; hydrogel; mathematical model; microchannel; microfluidic; pH; simulation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kurnia, J.C.; Birgersson, E.; Mujumdar, A.S. Computational Study of pH-sensitive Hydrogel-based Microfluidic Flow Controllers. J. Funct. Biomater. 2011, 2, 195-212.

AMA Style

Kurnia JC, Birgersson E, Mujumdar AS. Computational Study of pH-sensitive Hydrogel-based Microfluidic Flow Controllers. Journal of Functional Biomaterials. 2011; 2(3):195-212.

Chicago/Turabian Style

Kurnia, Jundika C.; Birgersson, Erik; Mujumdar, Arun S. 2011. "Computational Study of pH-sensitive Hydrogel-based Microfluidic Flow Controllers." J. Funct. Biomater. 2, no. 3: 195-212.



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