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J. Funct. Biomater. 2011, 2(3), 173-194; doi:10.3390/jfb2030173
Article

Temperature-Responsive Biocompatible Copolymers Incorporating Hyperbranched Polyglycerols for Adjustable Functionality

1,2,* , 2
, 3
 and 1,3
Received: 28 June 2011; in revised form: 9 August 2011 / Accepted: 12 August 2011 / Published: 23 August 2011
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Abstract: Temperature-triggered copolymers are proposed for a number of bio-applications but there is no ideal material platform, especially for injectable drug delivery. Options are needed for degradable biomaterials that not only respond to temperature but also easily accommodate linkage of active molecules. A first step toward realizing this goal is the design and synthesis of the novel materials reported herein. A multifunctional macromer, methacrylated hyperbranched polyglycerol (HPG-MA) with an average of one acrylate unit per copolymer, was synthesized and copolymerized with N-isopropylacrylamide (NIPAAm), hydroxyethyl methacrylate-polylactide (HEMAPLA) and acrylic acid (AAc). The potential to fully exploit the copolymers by modification of the multiple HPG hydroxyl groups will not be discussed here. Instead, this report focuses on the thermoresponsive, biocompatible, and degradation properties of the material. Poly(NIPAAm-co-HEMAPLA-co-AAc-co-HPG-MA) displayed increasing lower critical solution temperatures (LCST) as the HPG content increased over a range of macromer ratios. For the copolymer with the maximum HPG incorporation (17%), the LCST was ~30 °C. In addition, this sample showed no toxicity when human uterine fibroid cells were co-cultured with the copolymer for up to 72 h. This copolymer lost approximately 92% of its mass after 17 hours at 37 °C. Thus, the reported biomaterials offer attractive properties for the design of drug delivery systems where orthogonally triggered mechanisms of therapeutic release in relatively short time periods would be attractive.
Keywords: drug delivery; hyperbranched polyglycerol; temperature responsive; cell biocompatibility drug delivery; hyperbranched polyglycerol; temperature responsive; cell biocompatibility
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Taylor, D.K.; Jayes, F.L.; House, A.J.; Ochieng, M.A. Temperature-Responsive Biocompatible Copolymers Incorporating Hyperbranched Polyglycerols for Adjustable Functionality. J. Funct. Biomater. 2011, 2, 173-194.

AMA Style

Taylor DK, Jayes FL, House AJ, Ochieng MA. Temperature-Responsive Biocompatible Copolymers Incorporating Hyperbranched Polyglycerols for Adjustable Functionality. Journal of Functional Biomaterials. 2011; 2(3):173-194.

Chicago/Turabian Style

Taylor, Darlene K.; Jayes, Friederike L.; House, Alan J.; Ochieng, Melony A. 2011. "Temperature-Responsive Biocompatible Copolymers Incorporating Hyperbranched Polyglycerols for Adjustable Functionality." J. Funct. Biomater. 2, no. 3: 173-194.



J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert