Table of Contents
J. Clin. Med., Volume 7, Issue 2 (February 2018)
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Cover Story (view full-size image) The cover image represents 'moonlighting' by WDR5, a highly conserved protein that was first [...] Read more. The cover image represents 'moonlighting' by WDR5, a highly conserved protein that was first characterized in the context of histone methylation, but is now known to also act as a reader of the epigenetic 'code', a component of multiple chromatin modifying complexes, a co-factor for transcriptional regulators, and in mitotic regulation. We review the known functions of WDR5, discuss how a small, conserved, protein can achieve such versatility, consider how the multi-faceted actions of WDR5 need to be carefully considered when interpreting experimental results, and describe prospects for WDR5 as a target for anti-cancer agents. View this paper