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J. Clin. Med. 2018, 7(2), 29; https://doi.org/10.3390/jcm7020029

A Practical Review of the Emerging Direct Anticoagulants, Laboratory Monitoring, and Reversal Agents

1
Department of Cardiology, Mayo Clinic, Phoenix, AZ 85054, USA
2
Whipps Cross University Hospital, London E11 1NR, UK
3
Department of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, AZ 85054, USA
4
Center for Sleep Medicine, Mayo Clinic, Rochester, MN 55905, USA
5
Department of Cardiology, Mayo Clinic, Rochester, MN 55905, USA
6
Midwestern University, Glendale, AZ 85308, USA
*
Author to whom correspondence should be addressed.
Received: 15 November 2017 / Revised: 22 January 2018 / Accepted: 23 January 2018 / Published: 11 February 2018
(This article belongs to the Special Issue Image Guided Interventions and Emerging Technologies)
View Full-Text   |   Download PDF [218 KB, uploaded 11 February 2018]

Abstract

Millions of patients in the United States use anticoagulation for a variety of indications, such as the prevention of stroke in those with atrial fibrillation (AF) and the treatment and prevention of venous thrombosis. For over six decades warfarin was the only available oral anticoagulant, but now several DOACs are available and their use has become more prevalent in recent years. In spite of this increased use, many physicians remain reluctant to prescribe DOACs due to concerns about bleeding and reversibility. View Full-Text
Keywords: anticoagulants; serum levels; reversal agents anticoagulants; serum levels; reversal agents
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Joppa, S.A.; Salciccioli, J.; Adamski, J.; Patel, S.; Wysokinski, W.; McBane, R.; Al-Saffar, F.; Esser, H.; Shamoun, F. A Practical Review of the Emerging Direct Anticoagulants, Laboratory Monitoring, and Reversal Agents. J. Clin. Med. 2018, 7, 29.

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