Table of Contents
J. Clin. Med., Volume 6, Issue 8 (August 2017)
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Cover Story (view full-size image) Cardiovascular disease is predicted to account for >23 million by 2030. There is now consensus that [...] Read more. Cardiovascular disease is predicted to account for >23 million by 2030. There is now consensus that dyslipidaemia induces atherosclerosis. Statins have become the cornerstone for management of dyslipidaemia and have a very good safety profile. Nevertheless, potential risk of an adverse event must be considered when using statin therapy for patients. Statin-associated muscle disease (SAMS) is the most common reason for discontinuation of therapy. Reported incidence varies, ranging between 5% and 29%. Milder disease is common. The more serious form, rhabdomyolysis is rarer, with an incidence of roughly 1 in 10000. The pathophysiology of SAMS is not yet fully understood. Although literature points towards statin-induced mitochondrial dysfunction, exact mechanism is not yet elucidated. This paper details some of the different aetiological hypotheses related to mitochondrial dysfunction put forward in the literature. View this paper.