Next Article in Journal
The Fragility Index in a Cohort of Pediatric Randomized Controlled Trials
Previous Article in Journal
Ultrasound for Early Detection of Joint Disease in Patients with Hemophilic Arthropathy
Previous Article in Special Issue
Novel Pharmacological Activity of Artesunate and Artemisinin: Their Potential as Anti-Tubercular Agents
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessBrief Report
J. Clin. Med. 2017, 6(8), 78; doi:10.3390/jcm6080078

Impact of Larger Sputum Volume on Xpert® MTB/RIF Assay Detection of Mycobacterium tuberculosis in Smear-Negative Individuals with Suspected Tuberculosis

1
Clinical HIV Research Unit, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of Witwatersrand, Johannesburg 2092, South Africa
2
Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health Boston, Boston, MA 02115, USA
3
Instituto Nacional de Infectologia Evandro Chagas-INI-Fiocruz, Rio de Janeiro 21.045-900, Brazil
4
Pulmonary and Critical Care Department, Baylor Scott and White Hospital, Temple, TX 76508, USA
5
Social & Scientific Systems, Inc., Silver Spring, MD 20910, USA
6
Cepheid Inc., Sunnyvale, CA 94089, USA
7
Division of Infectious Disease, Rutgers-New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
8
Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
9
The Veterans Affairs Medical Center, The George Washington University, Washington, DC 20422, USA
10
Division of HIV, Infectious Diseases and Global Medicine, Zuckerberg San Francisco General, University of California, San Francisco, CA 94110, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Mehdi Mirsaeidi
Received: 23 May 2017 / Revised: 20 July 2017 / Accepted: 31 July 2017 / Published: 7 August 2017
(This article belongs to the Special Issue Tuberculosis Treatment and Management)
View Full-Text   |   Download PDF [200 KB, uploaded 7 August 2017]

Abstract

As a strategy to improve the sensitivity of nucleic acid-based testing in acid-fast bacilli (AFB) negative samples, larger volumes of sputum (5–10 mL) were tested with Xpert® MTB/RIF from 176 individuals with smear-negative sputum undergoing tuberculosis evaluation. Despite larger volumes, this strategy had a suboptimal sensitivity of 50% (4/8). View Full-Text
Keywords: larger volume sputum; Xpert MTB/RIF; smear-negative suspects larger volume sputum; Xpert MTB/RIF; smear-negative suspects
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Badal-Faesen, S.; Firnhaber, C.; Kendall, M.A.; Wu, X.; Grinsztejn, B.; Escada, R.O.S.; Fernandez, M.; Hogg, E.; Sanne, I.; Johnson, P.; Alland, D.; Mazurek, G.H.; Benator, D.A.; Luetkemeyer, A.F.; the AIDS Clinical Trials Group A5295; Tuberculosis Trials Consortium Study 34 Teams. Impact of Larger Sputum Volume on Xpert® MTB/RIF Assay Detection of Mycobacterium tuberculosis in Smear-Negative Individuals with Suspected Tuberculosis. J. Clin. Med. 2017, 6, 78.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top