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J. Clin. Med. 2017, 6(2), 22; doi:10.3390/jcm6020022

CVD and Oxidative Stress

Institute of Cardiovascular and Medical Sciences, University of Glasgow, BHF Glasgow Cardiovascular Research Centre, 126 University Place, Glasgow G12 8TA, UK
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Author to whom correspondence should be addressed.
Academic Editor: Francisco Dasí
Received: 1 December 2016 / Revised: 12 February 2017 / Accepted: 14 February 2017 / Published: 20 February 2017
(This article belongs to the Special Issue The Role of Oxidant Stress in Disease)
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Abstract

Nowadays, it is known that oxidative stress plays at least two roles within the cell, the generation of cellular damage and the involvement in several signaling pathways in its balanced normal state. So far, a substantial amount of time and effort has been expended in the search for a clear link between cardiovascular disease (CVD) and the effects of oxidative stress. Here, we present an overview of the different sources and types of reactive oxygen species in CVD, highlight the relationship between CVD and oxidative stress and discuss the most prominent molecules that play an important role in CVD pathophysiology. Details are given regarding common pharmacological treatments used for cardiovascular distress and how some of them are acting upon ROS-related pathways and molecules. Novel therapies, recently proposed ROS biomarkers, as well as future challenges in the field are addressed. It is apparent that the search for a better understanding of how ROS are contributing to the pathophysiology of CVD is far from over, and new approaches and more suitable biomarkers are needed for the latter to be accomplished. View Full-Text
Keywords: cardiovascular disease; CVD; oxidative stress; reactive oxygen species cardiovascular disease; CVD; oxidative stress; reactive oxygen species
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Cervantes Gracia, K.; Llanas-Cornejo, D.; Husi, H. CVD and Oxidative Stress. J. Clin. Med. 2017, 6, 22.

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