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J. Clin. Med. 2017, 6(3), 29; doi:10.3390/jcm6030029

Oxidative Stress: A New Target for Pancreatic Cancer Prognosis and Treatment

1
Translational Oncology Division, OncoHealth Institute, Health Research Institute, University Hospital Fundación Jiménez Díaz-UAM, 28040 Madrid, Spain
2
Facultad de Medicina, Universidad de Cartagena, Cartagena 2463, Colombia
*
Author to whom correspondence should be addressed.
Academic Editor: Francisco Dasí
Received: 29 November 2016 / Revised: 15 February 2017 / Accepted: 6 March 2017 / Published: 9 March 2017
(This article belongs to the Special Issue The Role of Oxidant Stress in Disease)
View Full-Text   |   Download PDF [542 KB, uploaded 9 March 2017]   |  

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of tumors, and its incidence is rising worldwide. Survival can be improved when tumors are detected at an early stage; however, this cancer is usually asymptomatic, and the disease only becomes apparent after metastasis. Several risk factors are associated to this disease. Chronic pancreatitis, diabetes, and some infectious disease are the most relevant risk factors. Incidence of PDAC has increased in the last decades. It is hypothesized it could be due to other acquired risk habits, like smoking, high alcohol intake, and obesity. Indeed, adipose tissue is a dynamic endocrine organ that secretes different pro-inflammatory cytokines, enzymes, and other factors that activate oxidative stress. Reactive oxygen species caused by oxidative stress, damage DNA, proteins, and lipids, and produce several toxic and high mutagenic metabolites that could modify tumor behavior, turning it into a malignant phenotype. Anti-oxidant compounds, like vitamins, are considered protective factors against cancer. Here, we review the literature on oxidative stress, the molecular pathways that activate or counteract oxidative stress, and potential treatment strategies that target reactive oxygen species suitable for this kind of cancer. View Full-Text
Keywords: oxidative stress; pancreatic cancer; cytokines; interleukins; ROS; anti-oxidants; vitamins oxidative stress; pancreatic cancer; cytokines; interleukins; ROS; anti-oxidants; vitamins
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Martinez-Useros, J.; Li, W.; Cabeza-Morales, M.; Garcia-Foncillas, J. Oxidative Stress: A New Target for Pancreatic Cancer Prognosis and Treatment. J. Clin. Med. 2017, 6, 29.

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