Airway Mucus and Asthma: The Role of MUC5AC and MUC5B
AbstractAsthma is characterized by mucus abnormalities. Airway epithelial hyperplasia and metaplasia result in changes in stored and secreted mucin and the production of a pathologic mucus gel. Mucus transport is impaired, culminating in mucus plugging and airway obstruction—a major cause of morbidity in asthma. The polymeric mucins MUC5AC and MUC5B are integral components of airway mucus. MUC5AC and MUC5B gene expression is altered in asthma, and recent work sheds light on their contribution to asthma pathogenesis. Herein, we review our current understanding of the role of MUC5AC and MUC5B in mucus dysfunction in asthma. View Full-Text
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Bonser, L.R.; Erle, D.J. Airway Mucus and Asthma: The Role of MUC5AC and MUC5B. J. Clin. Med. 2017, 6, 112.
Bonser LR, Erle DJ. Airway Mucus and Asthma: The Role of MUC5AC and MUC5B. Journal of Clinical Medicine. 2017; 6(12):112.Chicago/Turabian Style
Bonser, Luke R.; Erle, David J. 2017. "Airway Mucus and Asthma: The Role of MUC5AC and MUC5B." J. Clin. Med. 6, no. 12: 112.
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