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J. Clin. Med. 2017, 6(12), 112; doi:10.3390/jcm6120112

Airway Mucus and Asthma: The Role of MUC5AC and MUC5B

Lung Biology Center, University of California San Francisco, San Francisco, CA 94143, USA
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Received: 1 November 2017 / Revised: 25 November 2017 / Accepted: 27 November 2017 / Published: 29 November 2017
(This article belongs to the Special Issue Role of Respiratory Mucins in Health and Disease)
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Abstract

Asthma is characterized by mucus abnormalities. Airway epithelial hyperplasia and metaplasia result in changes in stored and secreted mucin and the production of a pathologic mucus gel. Mucus transport is impaired, culminating in mucus plugging and airway obstruction—a major cause of morbidity in asthma. The polymeric mucins MUC5AC and MUC5B are integral components of airway mucus. MUC5AC and MUC5B gene expression is altered in asthma, and recent work sheds light on their contribution to asthma pathogenesis. Herein, we review our current understanding of the role of MUC5AC and MUC5B in mucus dysfunction in asthma. View Full-Text
Keywords: MUC5AC; MUC5B; asthma MUC5AC; MUC5B; asthma
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Bonser, L.R.; Erle, D.J. Airway Mucus and Asthma: The Role of MUC5AC and MUC5B. J. Clin. Med. 2017, 6, 112.

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