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J. Clin. Med. 2017, 6(12), 110; doi:10.3390/jcm6120110

MUC1: The First Respiratory Mucin with an Anti-Inflammatory Function

1
Department of Otolaryngology, University of Arizona College of Medicine, Tucson, AZ 85724, USA
2
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
3
Department of Medicine, The First Hospital of Guangzhou Medical University, Guangzhou 510120, China
4
Departments of Physiology and Medicine, University of Arizona College of Medicine, Tucson, AZ 85724, USA
*
Author to whom correspondence should be addressed.
Received: 19 October 2017 / Revised: 22 November 2017 / Accepted: 24 November 2017 / Published: 29 November 2017
(This article belongs to the Special Issue Role of Respiratory Mucins in Health and Disease)
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Abstract

MUC1 is a membrane-bound mucin expressed on the apical surfaces of most mucosal epithelial cells. In normal lung epithelia, MUC1 is a binding site for Pseudomonas aeruginosa, an opportunistic human pathogen of great clinical importance. It has now been established that MUC1 also serves an anti-inflammatory role in the airways that is initiated late in the course of a bacterial infection and is mediated through inhibition of Toll-like receptor (TLR) signaling. MUC1 expression was initially shown to interfere with TLR5 signaling in response to P. aeruginosa flagellin, but has since been extended to other TLRs. These new findings point to an immunomodulatory role for MUC1 during P. aeruginosa lung infection, particularly during the resolution phase of inflammation. This review briefly summarizes the recent characterization of MUC1’s anti-inflammatory properties in both the respiratory tract and extrapulmonary tissues. View Full-Text
Keywords: MUC1; membrane-tethered mucin; lung; inflammation; Pseudomonas aeruginosa; Toll-like receptor MUC1; membrane-tethered mucin; lung; inflammation; Pseudomonas aeruginosa; Toll-like receptor
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kato, K.; Lillehoj, E.P.; Lu, W.; Kim, K.C. MUC1: The First Respiratory Mucin with an Anti-Inflammatory Function. J. Clin. Med. 2017, 6, 110.

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