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J. Clin. Med. 2017, 6(12), 111; doi:10.3390/jcm6120111

Viral Oncology: Molecular Biology and Pathogenesis

1
Center for Clinical Studies, Houston, TX 77004, USA
2
Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX 77004, USA
*
Author to whom correspondence should be addressed.
Received: 24 October 2017 / Revised: 17 November 2017 / Accepted: 22 November 2017 / Published: 29 November 2017
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Abstract

Oncoviruses are implicated in approximately 12% of all human cancers. A large number of the world’s population harbors at least one of these oncoviruses, but only a small proportion of these individuals go on to develop cancer. The interplay between host and viral factors is a complex process that works together to create a microenvironment conducive to oncogenesis. In this review, the molecular biology and oncogenic pathways of established human oncoviruses will be discussed. Currently, there are seven recognized human oncoviruses, which include Epstein-Barr Virus (EBV), Human Papillomavirus (HPV), Hepatitis B and C viruses (HBV and HCV), Human T-cell lymphotropic virus-1 (HTLV-1), Human Herpesvirus-8 (HHV-8), and Merkel Cell Polyomavirus (MCPyV). Available and emerging therapies for these oncoviruses will be mentioned. View Full-Text
Keywords: viral oncology; human oncovirus; EBV; HPV; HBV; HCV; HTLV-1; HHV-8; MCPyV viral oncology; human oncovirus; EBV; HPV; HBV; HCV; HTLV-1; HHV-8; MCPyV
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Mui, U.N.; Haley, C.T.; Tyring, S.K. Viral Oncology: Molecular Biology and Pathogenesis. J. Clin. Med. 2017, 6, 111.

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