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J. Clin. Med. 2014, 3(1), 88-134; doi:10.3390/jcm3010088
Review

Adult Stem Cells and Diseases of Aging

1,2
 and 1,2,3,*
Received: 20 November 2013; in revised form: 15 December 2013 / Accepted: 17 December 2013 / Published: 21 January 2014
(This article belongs to the Special Issue Frontiers in Stem Cell Treatments)
View Full-Text   |   Download PDF [616 KB, uploaded 21 January 2014]
Abstract: Preservation of adult stem cells pools is critical for maintaining tissue homeostasis into old age. Exhaustion of adult stem cell pools as a result of deranged metabolic signaling, premature senescence as a response to oncogenic insults to the somatic genome, and other causes contribute to tissue degeneration with age. Both progeria, an extreme example of early-onset aging, and heritable longevity have provided avenues to study regulation of the aging program and its impact on adult stem cell compartments. In this review, we discuss recent findings concerning the effects of aging on stem cells, contributions of stem cells to age-related pathologies, examples of signaling pathways at work in these processes, and lessons about cellular aging gleaned from the development and refinement of cellular reprogramming technologies. We highlight emerging therapeutic approaches to manipulation of key signaling pathways corrupting or exhausting adult stem cells, as well as other approaches targeted at maintaining robust stem cell pools to extend not only lifespan but healthspan.
Keywords: aging; stem cells; reprogramming; progeria; longevity; FoxO; Wnt; metabolic disease; oxidative stress aging; stem cells; reprogramming; progeria; longevity; FoxO; Wnt; metabolic disease; oxidative stress
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Boyette, L.B.; Tuan, R.S. Adult Stem Cells and Diseases of Aging. J. Clin. Med. 2014, 3, 88-134.

AMA Style

Boyette LB, Tuan RS. Adult Stem Cells and Diseases of Aging. Journal of Clinical Medicine. 2014; 3(1):88-134.

Chicago/Turabian Style

Boyette, Lisa B.; Tuan, Rocky S. 2014. "Adult Stem Cells and Diseases of Aging." J. Clin. Med. 3, no. 1: 88-134.

J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert