Special Issue "Frontiers in Stem Cell Treatments"
A special issue of Journal of Clinical Medicine (ISSN 2077-0383).
Deadline for manuscript submissions: closed (30 June 2013)
Prof. Dr. Frank Barry
Regenerative Medicine Institute (REMEDI), National Centre of Biomedical Engineering Science(NCBES), National University of Ireland, Galway, Ireland
Phone: +353 91 495108
Interests: biology of adult stem cells; tissue engineering; cell transplantation protocols; immunology of allogeneic cell transplantation; gene therapy; cell-based gene delivery; regulation of differentiation; mechanisms of engraftment and homing of transplanted stem cells; stem cell plasticity
There has been a great deal of interest in recent years in the use of stem cells in the treatment of a broad spectrum of diseases and many predictions have been made which suggest that the future practice of medicine will rely heavily on applications in stem cell technology. There has been steady progress in understanding the biological nature of stem cells, their isolation and expansion, and how they make fate decisions. One of the most significant steps has been the demonstration that mature somatic cells can be reprogrammed to become pluripotent. Indeed, the development of induced pluripotent stem (iPS) cell technology has opened doors into an extraordinary world of new understanding and clinical potential. This great achievement has been justly recognized by the award of the 2012 Nobel Prize in Physiology or Medicine to Sir John B. Gurdon and Shinya Yamanaka.
In addition to progress in understanding the fundamental nature of stem cells, there has also been an explosion of preclinical studies. These have been overwhelmingly positive and have, in study after study, pointed to the therapeutic promise of stem cells. They have taught us about the potential roles of stem cells in tissue regeneration, modulation of the immune system and paracrine mechanisms to stimulate a host response. Nonetheless, the clinical testing of stem cells in controlled, randomized trials has moved at a slow pace and for some the proof of concept is yet to be fully delivered.
There are many obstacles on the road to clinical testing, not least being an understanding of toxicology, mechanism of action and large scale expansion. The current special issue is designed to examine the clinical potential of stem cell therapy and provide a timely update on the current status of clinical trials.
Prof. Dr. Frank Barry
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- stem cells
- regenerative medicine
- clinical trials
- paracrine effects
- mesenchymal stem cells
Review: The Power and the Promise of Cell Reprogramming: Personalized Autologous Body Organ and Cell Transplantation
J. Clin. Med. 2014, 3(2), 373-387; doi:10.3390/jcm3020373
Received: 14 January 2014; in revised form: 17 February 2014 / Accepted: 19 February 2014 / Published: 4 April 2014| Download PDF Full-text (241 KB) | Download XML Full-text
Review: Towards a Treatment of Stress Urinary Incontinence: Application of Mesenchymal Stromal Cells for Regeneration of the Sphincter Muscle
J. Clin. Med. 2014, 3(1), 197-215; doi:10.3390/jcm3010197
Received: 13 December 2013; in revised form: 16 January 2014 / Accepted: 17 January 2014 / Published: 24 February 2014| Download PDF Full-text (2030 KB) | View HTML Full-text | Download XML Full-text
J. Clin. Med. 2014, 3(1), 88-134; doi:10.3390/jcm3010088
Received: 20 November 2013; in revised form: 15 December 2013 / Accepted: 17 December 2013 / Published: 21 January 2014| Download PDF Full-text (616 KB) | View HTML Full-text
J. Clin. Med. 2014, 3(1), 39-87; doi:10.3390/jcm3010039
Received: 6 October 2013; in revised form: 28 October 2013 / Accepted: 16 November 2013 / Published: 15 January 2014| Download PDF Full-text (877 KB) | View HTML Full-text | Download XML Full-text
J. Clin. Med. 2013, 2(4), 302-327; doi:10.3390/jcm2040302
Received: 9 October 2013; in revised form: 17 November 2013 / Accepted: 25 November 2013 / Published: 17 December 2013| Download PDF Full-text (382 KB) | View HTML Full-text | Download XML Full-text
J. Clin. Med. 2013, 2(4), 220-241; doi:10.3390/jcm2040220
Received: 29 August 2013; in revised form: 16 September 2013 / Accepted: 21 September 2013 / Published: 1 November 2013| Download PDF Full-text (351 KB) | View HTML Full-text
J. Clin. Med. 2013, 2(4), 201-213; doi:10.3390/jcm2040201
Received: 16 August 2013; in revised form: 10 September 2013 / Accepted: 27 September 2013 / Published: 23 October 2013| Download PDF Full-text (441 KB) | View HTML Full-text
J. Clin. Med. 2013, 2(3), 115-135; doi:10.3390/jcm2030115
Received: 25 July 2013; in revised form: 22 August 2013 / Accepted: 10 September 2013 / Published: 23 September 2013| Download PDF Full-text (1542 KB) | View HTML Full-text | Download XML Full-text
Article: Aging Impairs the Proliferative Capacity of Cardiospheres, Cardiac Progenitor Cells and Cardiac Fibroblasts: Implications for Cell Therapy
J. Clin. Med. 2013, 2(3), 103-114; doi:10.3390/jcm2030103
Received: 31 July 2013; in revised form: 9 August 2013 / Accepted: 22 August 2013 / Published: 23 September 2013| Download PDF Full-text (1078 KB) | View HTML Full-text | Download XML Full-text
Article: Short Term Culture of Human Mesenchymal Stem Cells with Commercial Osteoconductive Carriers Provides Unique Insights into Biocompatibility
J. Clin. Med. 2013, 2(3), 49-66; doi:10.3390/jcm2030049
Received: 30 May 2013; in revised form: 6 July 2013 / Accepted: 9 July 2013 / Published: 19 August 2013| Download PDF Full-text (917 KB) | View HTML Full-text | Download XML Full-text
Last update: 5 December 2012