Next Article in Journal
Neutrophils and Granulocytic MDSC: The Janus God of Cancer Immunotherapy
Next Article in Special Issue
Influenza and Memory T Cells: How to Awake the Force
Previous Article in Journal
Monitoring of the Immune Dysfunction in Cancer Patients
Previous Article in Special Issue
Highly-Immunogenic Virally-Vectored T-cell Vaccines Cannot Overcome Subversion of the T-cell Response by HCV during Chronic Infection
Article Menu

Export Article

Open AccessReview
Vaccines 2016, 4(3), 30; doi:10.3390/vaccines4030030

T-Regulatory Cells and Vaccination “Pay Attention and Do Not Neglect Them”: Lessons from HIV and Cancer Vaccine Trials

1
Institut National de la Santé et de la Recherche Médicale (INSERM), U955, Equipe 16, Créteil 94000, France
2
Faculté de médecine, Université Paris Est, Créteil 94000, France
3
Vaccine Research Institute (VRI), Créteil 94000, France
4
Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
5
AP-HP, Hôpital H. Mondor—A. Chenevier, Service d’immunologie clinique et maladies infectieuses, Créteil 94000, France
*
Author to whom correspondence should be addressed.
Academic Editor: Stephen Todryk
Received: 15 June 2016 / Revised: 18 August 2016 / Accepted: 26 August 2016 / Published: 5 September 2016
(This article belongs to the Special Issue T Cell Memory to Vaccination)
View Full-Text   |   Download PDF [226 KB, uploaded 5 September 2016]

Abstract

Efficient vaccines are characterized by the establishment of long-lived memory T cells, including T-helper (effectors and follicular) and T-regulatory cells (Tregs). While the former induces cytotoxic or antibody responses, the latter regulates immune responses by maintaining homeostasis. The role of Tregs in inflammatory conditions is ambiguous and their systematic monitoring in vaccination along with effector T-cells is not instinctive. Recent studies from the cancer field clearly showed that Tregs suppress vaccine-induced immune responses and correlate with poor clinical benefit. In HIV infection, Tregs are needed during acute infection to preserve tissue integrity from an overwhelmed activation, but are not beneficial in chronic infection as they suppress anti-HIV responses. Current assays used to evaluate vaccine-induced specific responses are limited as they do not take into account antigen-specific Tregs. However, new assays, such as the OX40 assay, which allow for the simultaneous detection of a full range of Th-responses including antigen-specific Tregs responses, can overcome these issues. In this review article we will revise the role of Tregs in vaccination and review the recent work performed in the field, including the available tools to monitor them, from novel assays to humanized mouse models. View Full-Text
Keywords: memory cell; Tregs; HIV; vaccine; DC-based vaccine; OX40; CD25; CD39; hu-mice memory cell; Tregs; HIV; vaccine; DC-based vaccine; OX40; CD25; CD39; hu-mice
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Brezar, V.; Godot, V.; Cheng, L.; Su, L.; Lévy, Y.; Seddiki, N. T-Regulatory Cells and Vaccination “Pay Attention and Do Not Neglect Them”: Lessons from HIV and Cancer Vaccine Trials. Vaccines 2016, 4, 30.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Vaccines EISSN 2076-393X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top