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Vaccines 2016, 4(3), 25; doi:10.3390/vaccines4030025

Immunological Evaluation of Recent MUC1 Glycopeptide Cancer Vaccines

Department of Medicinal and Biological Chemistry, University of Toledo, Toledo, OH 43606, USA
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Author to whom correspondence should be addressed.
Academic Editor: Diane M. Harper
Received: 19 April 2016 / Revised: 13 July 2016 / Accepted: 21 July 2016 / Published: 26 July 2016
(This article belongs to the Special Issue Glycopeptide-based and Related Vaccines)
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Abstract

Aberrantly glycosylated mucin 1 (MUC1) is a recognized tumor-specific antigen on epithelial cell tumors. A wide variety of MUC1 glycopeptide anti-cancer vaccines have been formulated by many research groups. Some researchers have used MUC1 alone as an immunogen whereas other groups used different antigenic carrier proteins such as bovine serum albumin or keyhole limpet hemocyanin for conjugation with MUC1 glycopeptide. A variety of adjuvants have been used with MUC1 glycopeptides to improve their immunogenicity. Fully synthetic multicomponent vaccines have been synthesized by incorporating different T helper cell epitopes and Toll-like receptor agonists. Some vaccine formulations utilized liposomes or nanoparticles as vaccine delivery systems. In this review, we discuss the immunological evaluation of different conjugate or synthetic MUC1 glycopeptide vaccines in different tumor or mouse models that have been published since 2012. View Full-Text
Keywords: MUC1; adjuvant; BSA; KLH; TLR; liposome; vaccine MUC1; adjuvant; BSA; KLH; TLR; liposome; vaccine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Hossain, M.K.; Wall, K.A. Immunological Evaluation of Recent MUC1 Glycopeptide Cancer Vaccines. Vaccines 2016, 4, 25.

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