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Vaccines 2016, 4(1), 6; doi:10.3390/vaccines4010006

Hepatitis Vaccines

Division of Pediatric Gastroenterology and Nutrition, Pediatric Liver Center, Johns Hopkins Medical Institutions, CMSC 2-125, 600 North Wolfe Street, Baltimore, MD 21287, USA
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Author to whom correspondence should be addressed.
Academic Editor: Diane M. Harper
Received: 4 November 2015 / Revised: 11 January 2016 / Accepted: 14 January 2016 / Published: 11 March 2016
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Abstract

Viral hepatitis is a serious health problem all over the world. However, the reduction of the morbidity and mortality due to vaccinations against hepatitis A and hepatitis B has been a major component in the overall reduction in vaccine preventable diseases. We will discuss the epidemiology, vaccine development, and post-vaccination effects of the hepatitis A and B virus. In addition, we discuss attempts to provide hepatitis D vaccine for the 350 million individuals infected with hepatitis B globally. Given the lack of a hepatitis C vaccine, the many challenges facing the production of a hepatitis C vaccine will be shown, along with current and former vaccination trials. As there is no current FDA-approved hepatitis E vaccine, we will present vaccination data that is available in the rest of the world. Finally, we will discuss the existing challenges and questions facing future endeavors for each of the hepatitis viruses, with efforts continuing to focus on dramatically reducing the morbidity and mortality associated with these serious infections of the liver. View Full-Text
Keywords: hepatitis A, B, C, D, and E; vaccines hepatitis A, B, C, D, and E; vaccines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ogholikhan, S.; Schwarz, K.B. Hepatitis Vaccines. Vaccines 2016, 4, 6.

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