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Vaccines 2015, 3(1), 90-104; doi:10.3390/vaccines3010090

Assaying the Potency of Influenza Vaccines

National Institute for Biological Standards and Control/MHRA, Blanche Lane, Potters Bar, Hertfordshire EN6 3QG, UK
Academic Editor: Sarah Gilbert
Received: 3 November 2014 / Revised: 3 December 2014 / Accepted: 27 January 2015 / Published: 5 February 2015
(This article belongs to the Special Issue Influenza Vaccines)
View Full-Text   |   Download PDF [312 KB, uploaded 5 February 2015]   |  

Abstract

The potency of vaccines must be determined to ensure that the appropriate dose is given. The manufacture and assessment of influenza vaccines are complicated by the continuously changing nature of the pathogen, which makes efficacy estimates difficult but also confounds attempts to produce a well-validated, consistent potency assay. Single radial diffusion has been used for decades and provides a relatively simple way to measure the amount of biologically active materials present in the vaccine. It requires reagents, which are updated on a regular, frequently yearly, basis and alternative methods continue to be sought. View Full-Text
Keywords: influenza vaccine; potency; SRD; reagent calibration; Influenza Collaborating Centres; Essential Regulatory Laboratories influenza vaccine; potency; SRD; reagent calibration; Influenza Collaborating Centres; Essential Regulatory Laboratories
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Minor, P.D. Assaying the Potency of Influenza Vaccines. Vaccines 2015, 3, 90-104.

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