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Vaccines 2015, 3(1), 74-89; doi:10.3390/vaccines3010074

EBV-Associated Cancer and Autoimmunity: Searching for Therapies

1
Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari 70126, Italy
2
Brain and Language Laboratory, Free University of Berlin, 14195 Berlin, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Lenora (Nora) Disis
Received: 25 September 2014 / Revised: 12 December 2014 / Accepted: 27 January 2015 / Published: 5 February 2015
(This article belongs to the Special Issue Cancer Vaccines)
View Full-Text   |   Download PDF [368 KB, uploaded 5 February 2015]   |  

Abstract

Epstein-Barr virus (EBV) infects B-, T-, and NK cells and has been associated not only with a wide range of lymphoid malignancies but also with autoimmune diseases such as lupus erythematosus, rheumatoid arthritis and, in particular, multiple sclerosis. Hence, effective immunotherapeutic approaches to eradicate EBV infection might overthrow cancer and autoimmunity incidence. However, currently no effective anti-EBV immunotherapy is available. Here we use the concept that protein immunogenicity is allocated in rare peptide sequences and search the Epstein-Barr nuclear antigen 1 (EBNA1) sequence for peptides unique to the viral protein and absent in the human host. We report on a set of unique EBV EBNA1 peptides that might be used in designing peptide-based therapies able to specifically hitting the virus or neutralizing pathogenic autoantibodies. View Full-Text
Keywords: EBV EBNA1; cancer; autoimmunity; peptide matching; low-similarity peptides; anti-EBV vaccine; peptide-therapy EBV EBNA1; cancer; autoimmunity; peptide matching; low-similarity peptides; anti-EBV vaccine; peptide-therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Capone, G.; Fasano, C.; Lucchese, G.; Calabrò, M.; Kanduc, D. EBV-Associated Cancer and Autoimmunity: Searching for Therapies. Vaccines 2015, 3, 74-89.

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